Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 26, 2020; 8(10): 1887-1896
Published online May 26, 2020. doi: 10.12998/wjcc.v8.i10.1887
Outcomes of patients with pelvic leiomyosarcoma treated by surgery and relevant auxiliary diagnosis
Qian Sun, Xin Yang, Zhen Zeng, Xiao Wei, Ke-Zhen Li, Xiao-Yan Xu
Qian Sun, Xin Yang, Zhen Zeng, Xiao Wei, Ke-Zhen Li, Xiao-Yan Xu, Department of Obstetrics and Gynaecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Author contributions: Sun Q and Yang X designed and performed the research; Wei X and Zeng Z conceptualized the study and analyzed the clinical data; Li KZ and Xu XY supervised the study; Sun Q and Yang X contributed equally to this work; all authors approved the submitted version.
Supported by National Natural Science Foundation of China, No. 81501530; Scientific Research Projects of Hubei Health Commission, No. WJ2019M130; and Scientific Research Fund of Tongji Hospital, No. 2018B02.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.
Informed consent statement: The analysis used anonymous clinical data obtained from each patient who agreed to the treatment by written consent.
Conflict-of-interest statement: The authors declare no conflict of interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao-Yan Xu, PhD, Doctor, Department of Obstetrics and Gynaecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan 430030, Hubei Province, China. xuxiaoyan@tjh.tjmu.edu.cn
Received: December 30, 2019
Peer-review started: December 30, 2019
First decision: April 1, 2020
Revised: April 7, 2020
Accepted: April 22, 2020
Article in press: April 22, 2020
Published online: May 26, 2020
Processing time: 146 Days and 20.4 Hours
ARTICLE HIGHLIGHTS
Research background

Leimyosarcoma of the pelvic cavity heavily affects the health and life of women, but clinical characteristics and relevant diagnosis of the disease are still unclear. It is necessary to carry out clinical research related to pelvic leiomyosarcoma.

Research motivation

Preoperative diagnosis of pelvic leiomyosarcoma is very difficult, and only the pathological examination after operation can provide an accurate diagnosis for this disease. We would like to study the causes affecting diagnosis and factors affecting outcomes of those patients.

Research objectives

This study aimed to identify the outcomes and relevant perioperative evaluation of patients with pelvic leiomyosarcoma.

Research methods

We used Kaplan-Meier method to determine progression-free survival and overall survival rates. Univariate and multivariate Cox proportional hazards models were used to comprehensively analyse the prognostic factors

Research results

The results indicated that serum biomarkers had limited ability in leiomyosarcoma diagnosis and ultrasonography could not accurately differentiate leiomyosarcoma from uterine leiomyoma. However, most of the recurrent lesions could be detected using ultrasonography. FIGO stage was significantly associated with poor progression-free survival in the univariate and multivariate analyses.

Research conclusions

Serum tumour markers and ultrasonography cannot accurately diagnose pelvic leiomyosarcoma. Ultrasonography remains valuable in monitoring recurrence. FIGO stage is significantly associated with patient outcomes.

Research perspectives

Although accurate preoperative diagnosis of pelvic leiomyosarcoma was very difficult, our results showed that FIGO stage was significantly related to prognosis. Therefore, improving the early diagnosis rate is a promising field in the future.