Systematic Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2019; 7(19): 2995-3011
Published online Oct 6, 2019. doi: 10.12998/wjcc.v7.i19.2995
Treatment of laryngopharyngeal reflux disease: A systematic review
Jerome R Lechien, Francois Mouawad, Maria R Barillari, Andrea Nacci, Seyyedeh Maryam Khoddami, Necati Enver, Sampath Kumar Raghunandhan, Christian Calvo-Henriquez, Young-Gyu Eun, Sven Saussez
Jerome R Lechien, Sven Saussez, Laboratory of Anatomy and Cell Biology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons, Mons 7000, Belgium
Jerome R Lechien, Francois Mouawad, Maria R Barillari, Andrea Nacci, Seyyedeh Maryam Khoddami, Necati Enver, Sampath Kumar Raghunandhan, Christian Calvo-Henriquez, Young-Gyu Eun, Sven Saussez, Laryngopharyngeal Reflux Study Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies, Paris 75000, France
Francois Mouawad, Department of Otolaryngology-Head and Neck Surgery, CHU de Lille, Lille 59000, France
Maria R Barillari, Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples 80100, Italy
Andrea Nacci, ENT Audiology and Phoniatric Unit, University of Pisa, Pisa 56100, Italy
Seyyedeh Maryam Khoddami, Larynx Function and Acoustic Voice Laboratory, Department of Speech Therapy, School of Rehabilitation, Tehran 11369, Iran
Necati Enver, Department of Otolaryngology, Marmara University Pendik Training and Research Hospital, Istanbul 34722, Turkey
Sampath Kumar Raghunandhan, Department of Otology, Neurotology and Skullbase Surgery, Madras ENT Research Foundation, Tamil Nadu 60028, India
Christian Calvo-Henriquez, Department of Otorhinolaryngology and Head and Neck Surgery, Hospital Complex of Santiago de Compostela, Santiago de Compostela 15700, Spain
Young-Gyu Eun, Department of Otorhinolaryngology and Head and Neck Surgery, Kyung Hee University Medical Center, Seoul 130702, Korea
Author contributions: Lechien JR, Mouawad F, Saussez S, Eun Y substantial contributed to the conception or design of the work; made the acquisition, analysis, or interpretation of data for the work; drafted the work; made final approval of the version to be published; agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Barillari M and Calvo-Henriquez C substantial contributed to the conception or design of the work; made the acquisition (systematic review performing); made the interpretation of data; agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Khoddami SM, Raghunandhan SK, Enver N, Nacci A made the interpretation of data, discussion improvement, agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Conflict-of-interest statement: The authors declare no conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jerome R Lechien, MD, MSc, PhD, Associate Professor, Laboratory of Anatomy and Cell Biology, Faculty of Medicine, University of Mons (UMONS), Avenue du Champ de mars, 6, Mons B7000, Belgium. jerome.lechien@umons.ac.be
Telephone: +32-65-373584
Received: March 28, 2019
Peer-review started: March 28, 2019
First decision: May 31, 2019
Revised: September 5, 2019
Accepted: September 11, 2019
Article in press: September 11, 2019
Published online: October 6, 2019
Processing time: 185 Days and 19.3 Hours
ARTICLE HIGHLIGHTS
Research background

For a long time, laryngopharyngeal reflux disease (LPRD) has been treated by proton pump inhibitors (PPIs) with an uncertain success rate.

Research motivation

The low success rate of PPIs as well as the cost of unsuccessful empirical therapeutic trials are important in otolaryngology. Many treatments of LPRD exist and we want to provide an analysis of the current therapeutic approach of this prevalent disease.

Research objectives

To shed light the current therapeutic strategies used for LPRD in order to analysis the rationale in the LPRD treatment.

Research methods

Three authors conducted a PubMed systematic review respecting PRISMA statements.

Research results

The majority of studies consists of empirical therapeutic trials using PPIs as single drug. The success rate of PPIs ranges from 18% to 87% and there is an important heterogeneity between studies according to the diagnostic, the therapeutic outcomes and the duration of treatment.

Research conclusions

The majority of treatments in LPRD are empirical and based on PPIs. The empirical therapeutic trial with PPIs is however associated with an uncertain success rate.