Published online Jul 6, 2019. doi: 10.12998/wjcc.v7.i13.1623
Peer-review started: February 27, 2019
First decision: March 27, 2019
Revised: April 17, 2019
Accepted: May 2, 2019
Article in press: May 3, 2019
Published online: July 6, 2019
Processing time: 129 Days and 19.2 Hours
Current research has identified several risk factors for refractory benign esophageal strictures (RBES), but research is scarce on the prediction of RBES in benign esophageal strictures patients. Meanwhile, the long-term outcomes of RBES remain unclear. The aim of this study was to develop and validate a model to determine the progression of RBES in patients with benign esophageal strictures. And we also explored the long-term outcomes and safety in patients with RBES.
To our knowledge, the present study is the largest sample research of benign esophageal strictures, and our observation indicators are complete, the follow-up period is long, the results are credible, and there is strong reference significance in clinical work.
The aim of this study was to develop and validate a model to determine the progression of RBES in patients with benign esophageal strictures.
A total of 507 benign esophageal stricture patients treated by dilation alone or in combination with stenting were retrospectively enrolled.
Among 507 patients, 57 were with RBES (39 males; median age, 60 years). The age, etiology, and number and length of strictures were the independent risk factors for the refractory performance of benign esophageal strictures. According to risk factors of benign esophageal strictures, a risk-scoring model for predicting RBES in benign esophageal strictures was established; the risk score ranged from 0 to 8 points, and the risk scores were divided into low (0-2 points), intermediate (3-5 points), and high risk (6-8 points). The proportions of RBES in the corresponding risk categories were 1.0%, 12.2%, and 76.0%, respectively.
The risk-scoring model predicting RBES in benign esophageal strictures could predict the long-term outcome of patients with strictures ahead.
The present study is a retrospective study to develop and validate a model to determine the progression of RBES in patients with benign esophageal strictures. Future case-control studies and prospective studies are required to confirm our findings.