He YH, Lu L, Wang YF, Huang JS, Zhu WQ, Guo Y, Li CX, Li HM. Acetaminophen-induced acute pancreatitis: A case report and literature review. World J Clin Cases 2018; 6(9): 291-295 [PMID: 30211210 DOI: 10.12998/wjcc.v6.i9.291]
Corresponding Author of This Article
Hua-Ming Li, MAMS, Doctor, Department of Gastroenterology, Hangzhou Third People’s Hospital, Zhejiang Chinese Medical University, No. 548 Binwen Road, No. 38 West Lake Road, Hangzhou 310000, Zhejiang Province, China. lhm133433@163.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 6, 2018; 6(9): 291-295 Published online Sep 6, 2018. doi: 10.12998/wjcc.v6.i9.291
Acetaminophen-induced acute pancreatitis: A case report and literature review
Ya-Hong He, Lei Lu, Yu-Fang Wang, Jin-Song Huang, Wei-Qin Zhu, Yan Guo, Chun-Xia Li, Hua-Ming Li
Ya-Hong He, Yu-Fang Wang, Jin-Song Huang, Wei-Qin Zhu, Yan Guo, Chun-Xia Li, Hua-Ming Li, Department of Gastroenterology, Hangzhou Third People’s Hospital, Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, China
Lei Lu, Department of Gastroenterology, Hangzhou First People’s Hospital, Nanjing Medical University, Hangzhou 310000, Zhejiang Province, China
Author contributions: All authors contributed to the acquisition of data, writing, and revision of this manuscript.
Informed consent statement: The patient and her family provided informed written consent.
Conflict-of-interest statement: All the authors have no conflicts of interests to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hua-Ming Li, MAMS, Doctor, Department of Gastroenterology, Hangzhou Third People’s Hospital, Zhejiang Chinese Medical University, No. 548 Binwen Road, No. 38 West Lake Road, Hangzhou 310000, Zhejiang Province, China. lhm133433@163.com
Telephone: +86-571-87823158
Received: March 25, 2018 Peer-review started: March 25, 2018 First decision: April 26, 2018 Revised: June 18, 2018 Accepted: June 27, 2018 Article in press: June 27, 2018 Published online: September 6, 2018 Processing time: 167 Days and 18.8 Hours
ARTICLE HIGHLIGHTS
Case characteristics
A 32-year-old woman presented with nausea and vomiting for 12 h associated with dizziness and epigastric pain.
Clinical diagnosis
Acetaminophen-induced acute pancreatitis.
Differential diagnosis
Biliary pancreatitis, alcohol-induced pancreatitis, hyperlipidemic pancreatitis and codeine-induced pancreatitis.
Laboratory diagnosis
Laboratory workup revealed a significant elevation of serum amylase of 990 U/L but normal aminotransferases.
Imaging diagnosis
Magnetic resonance cholangiopancreatography showed that the pancreas was bulky without exudation. Computed tomography demonstrated swelling of the pancreas, especially the head of the pancreas, with fluid collection around the pancreas.
Treatment
Abrosia, routine treatment for pancreatitis, and N-acetylcysteine were administered to the patient.
Related reports
A total of eleven cases of acetaminophen-induced acute pancreatitis have been reported in the literature but this case took the lowest dose of acetaminophen without liver damage.
Experiences and lessons
Acetaminophen-induced acute pancreatitis is rare and should be considered in the differential diagnosis of acute pancreatitis, especially in high-risk patients with an overdose of suspected drugs.
