Emre A, Akbulut S, Sertkaya M, Bitiren M, Kale IT, Bulbuloglu E, Colak C. Assessment of clinical and pathological features of patients who underwent thyroid surgery: A retrospective clinical study. World J Clin Cases 2018; 6(3): 20-26 [PMID: 29564354 DOI: 10.12998/wjcc.v6.i3.20]
Corresponding Author of This Article
Sami Akbulut, MD, Associate Professor, Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Elazig Yolu 10.Km, Malatya 44280, Turkey. akbulutsami@gmail.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 16, 2018; 6(3): 20-26 Published online Mar 16, 2018. doi: 10.12998/wjcc.v6.i3.20
Assessment of clinical and pathological features of patients who underwent thyroid surgery: A retrospective clinical study
Arif Emre, Sami Akbulut, Mehmet Sertkaya, Muharrem Bitiren, Ilhami Taner Kale, Ertan Bulbuloglu, Cemil Colak
Arif Emre, Mehmet Sertkaya, Ilhami Taner Kale, Ertan Bulbuloglu, Department of Surgery, Kahramanmaras Sutcu Imam University Faculty of Medicine, Kahramanmaras 46040, Turkey
Sami Akbulut, Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Turkey
Muharrem Bitiren, Department of Pathology, Kahramanmaras Sutcu Imam University Faculty of Medicine, Kahramanmaras 46100, Turkey
Cemil Colak, Department of Biostatistics, Inonu University Faculty of Medicine, Malatya 44280, Turkey
Author contributions: Emre A contributed to the data collection and manuscript writing; Akbulut S contributed to the project development and manuscript writing; Sertkaya M contributed to the data collection; Bitiren M contributed to the histopathologic examination; Kale IT contributed to the data collection; Bulbuloglu E contributed to the data collection; and Colak C contributed to the statistical analysis.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Kahramanmaras Sutcu Imam University Faculty of Medicine.
Informed consent statement: Patients were not required to give informed consent for the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Data sharing statement: There are no additional data available for this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sami Akbulut, MD, Associate Professor, Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Elazig Yolu 10.Km, Malatya 44280, Turkey. akbulutsami@gmail.com
Telephone: +90-422-3410660 Fax: +90-422-3410036
Received: October 31, 2017 Peer-review started: November 1, 2017 First decision: November 20, 2017 Revised: December 31, 2017 Accepted: February 28, 2018 Article in press: February 28, 2018 Published online: March 16, 2018 Processing time: 134 Days and 10.9 Hours
ARTICLE HIGHLIGHTS
Research objectives
The main objectives of this retrospective trial study were to evaluate whether there was any correlation between the clinical parameters and final pathological results among patients who underwent thyroid surgery.
Research methods
We retrospectively analyzed the demographic, clinical and histopathological parameters of 505 patients who underwent thyroid surgery. The patients were divided into malignant (n = 92) and benign (n = 413) groups depending on the final pathological results. We analyzed whether there was any difference between the groups in terms of demographic and clinical parameters.
Research results
No significant differences were found between the groups with respect to age, sex, WBC count, neutrophil count, lymphocyte count, thrombocyte count, RDW, PDW, MPV, PCT, nodule localization, and thyroid function testing. On the other hand, there were significant differences between the groups with respect to nodule size, cervical lymphadenopathy and nodular calcification. The correlation between FNAB and final pathological results was assessed using the cross-table method, and the sensitivity and specificity for FNAB were 60% and 98%, respectively.
Research conclusions
This study showed that significant differences existed between the malignant and benign groups with regard to nodule size, cervical lymphadenopathy, and nodular calcification.
