Liu QB, Zheng R. Natural killer/T-cell lymphoma with concomitant syndrome of inappropriate antidiuretic hormone secretion: A case report and review of literature. World J Clin Cases 2018; 6(13): 694-702 [PMID: 30430128 DOI: 10.12998/wjcc.v6.i13.694]
Corresponding Author of This Article
Rui Zheng, MD, PhD, Doctor, Professor, Teacher, Department of Respiratory Medicine, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. zhengr@sj-hospital.org
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 6, 2018; 6(13): 694-702 Published online Nov 6, 2018. doi: 10.12998/wjcc.v6.i13.694
Natural killer/T-cell lymphoma with concomitant syndrome of inappropriate antidiuretic hormone secretion: A case report and review of literature
Quan-Bo Liu, Rui Zheng
Quan-Bo Liu, Rui Zheng, Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Zheng R and Liu QB designed the report; Liu QB collected the patient’s clinical data and wrote the paper.
Informed consent statement: The patient was not required to give informed consent to the study because the analysis used anonymous data that were obtained after the patient gave written consent for treatment.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Rui Zheng, MD, PhD, Doctor, Professor, Teacher, Department of Respiratory Medicine, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. zhengr@sj-hospital.org
Received: July 31, 2018 Peer-review started: July 31, 2018 First decision: August 31, 2018 Revised: October 3, 2018 Accepted: October 11, 2018 Article in press: October 11, 2018 Published online: November 6, 2018 Processing time: 98 Days and 5.5 Hours
ARTICLE HIGHLIGHTS
Case characteristics
A 64-year-old woman was admitted with intermittent fever for 2 mo.
Clinical diagnosis
Stage 4B natural killer (NK)/T-cell lymphoma with concomitant syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Differential diagnosis
Infection, typhia, brucellosis, etc.
Laboratory diagnosis
As determined by blood and urine sampling examination, serum Na+ was 109.3 mmol/L, urea was 2.99 mmol/L, serum creatinine was 47.8 μmol/L, plasma osmolality was 235.39 mOsm/kg, and urine osmolality was 494 mOsm/kg.
Imaging diagnosis
Positron emission tomography-computed tomography indicated multiple swollen lymph nodes throughout the body accompanied by increased fluorodeoxyglucose metabolism, consistent with lymphoma.
Pathological diagnosis
Biopsy of the left submandibular lymph nodes confirmed NK/T-cell lymphoma.
Treatment
Chemotherapy, fluid restriction, and administration of sodium chloride.
Related reports
This is the first known report of NK/T-cell lymphoma with concomitant SIADH in PubMed.
Term explanation
Lymphoma is one of the causes of SIADH; however, NK/T-cell lymphoma with concomitant SIADH has not been reported.
Experiences and lessons
This case report emphasizes the importance of monitoring serum ions and etiological treatment in patients with NK/T-cell lymphoma.
