Case Report
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2018; 6(13): 694-702
Published online Nov 6, 2018. doi: 10.12998/wjcc.v6.i13.694
Natural killer/T-cell lymphoma with concomitant syndrome of inappropriate antidiuretic hormone secretion: A case report and review of literature
Quan-Bo Liu, Rui Zheng
Quan-Bo Liu, Rui Zheng, Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Zheng R and Liu QB designed the report; Liu QB collected the patient’s clinical data and wrote the paper.
Informed consent statement: The patient was not required to give informed consent to the study because the analysis used anonymous data that were obtained after the patient gave written consent for treatment.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Rui Zheng, MD, PhD, Doctor, Professor, Teacher, Department of Respiratory Medicine, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. zhengr@sj-hospital.org
Telephone: +86-2496-61521211 Fax: +86-2496-61572116
Received: July 31, 2018
Peer-review started: July 31, 2018
First decision: August 31, 2018
Revised: October 3, 2018
Accepted: October 11, 2018
Article in press: October 11, 2018
Published online: November 6, 2018
Processing time: 98 Days and 5.5 Hours
ARTICLE HIGHLIGHTS
Case characteristics

A 64-year-old woman was admitted with intermittent fever for 2 mo.

Clinical diagnosis

Stage 4B natural killer (NK)/T-cell lymphoma with concomitant syndrome of inappropriate antidiuretic hormone secretion (SIADH).

Differential diagnosis

Infection, typhia, brucellosis, etc.

Laboratory diagnosis

As determined by blood and urine sampling examination, serum Na+ was 109.3 mmol/L, urea was 2.99 mmol/L, serum creatinine was 47.8 μmol/L, plasma osmolality was 235.39 mOsm/kg, and urine osmolality was 494 mOsm/kg.

Imaging diagnosis

Positron emission tomography-computed tomography indicated multiple swollen lymph nodes throughout the body accompanied by increased fluorodeoxyglucose metabolism, consistent with lymphoma.

Pathological diagnosis

Biopsy of the left submandibular lymph nodes confirmed NK/T-cell lymphoma.

Treatment

Chemotherapy, fluid restriction, and administration of sodium chloride.

Related reports

This is the first known report of NK/T-cell lymphoma with concomitant SIADH in PubMed.

Term explanation

Lymphoma is one of the causes of SIADH; however, NK/T-cell lymphoma with concomitant SIADH has not been reported.

Experiences and lessons

This case report emphasizes the importance of monitoring serum ions and etiological treatment in patients with NK/T-cell lymphoma.