Published online Feb 16, 2024. doi: 10.12998/wjcc.v12.i5.880
Peer-review started: October 16, 2023
First decision: November 28, 2023
Revised: December 12, 2023
Accepted: January 16, 2024
Article in press: January 16, 2024
Published online: February 16, 2024
Processing time: 106 Days and 19.5 Hours
Some clinical studies have suggested that gastroesophageal reflux disease (GERD) may have a causal relationship with essential hypertension, but the relevant conclusions may be affected by confounding factors and small sample sizes.
Determining the causal relationship between GERD and essential hypertension could provide new perspectives for the treatment of patients with GERD and hypertension.
We would perform a bidirectional Mendelian randomization (MR) analysis to investigate the causal link between GERD and essential hypertension.
A series of steps were conducted to select eligible single nucleotide polymorphisms, and inverse variance weighted (IVW), weighted median and MR egger regression were used to examine whether there was a causal association between GERD and hypertension.
IVW analysis exhibited an increased risk of hypertension (OR = 1.46, 95%CI: 1.33-1.59, P = 2.14E-16) in GERD patients. Meanwhile, the IVW analysis showed an increased risk of systolic blood pressure and hypertensive heart disease in GERD patients.
GERD was positively associated with the risk of essential hypertension, suggesting a new prevent strategy and therapeutic perspectives of essential hypertension in patients with GERD.
The specific mechanisms associated with GERD and essential hypertension need to be further clarified.