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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Utility of plasma D-dimer for diagnosis of venous thromboembolism after hepatectomy
Taiichiro Miyake, Hiroaki Yanagimoto, Daisuke Tsugawa, Masayuki Akita, Riki Asakura, Keisuke Arai, Toshihiko Yoshida, Shinichi So, Jun Ishida, Takeshi Urade, Yoshihide Nanno, Kenji Fukushima, Hidetoshi Gon, Shohei Komatsu, Sadaki Asari, Hirochika Toyama, Masahiro Kido, Tetsuo Ajiki, Takumi Fukumoto
Taiichiro Miyake, Hiroaki Yanagimoto, Daisuke Tsugawa, Masayuki Akita, Riki Asakura, Keisuke Arai, Toshihiko Yoshida, Shinichi So, Jun Ishida, Takeshi Urade, Yoshihide Nanno, Kenji Fukushima, Hidetoshi Gon, Shohei Komatsu, Sadaki Asari, Hirochika Toyama, Masahiro Kido, Tetsuo Ajiki, Takumi Fukumoto, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan
Author contributions: Miyake T and Yanagimoto H involved in the project development and data management; Miyake T, Yanagimoto H, Tsugawa D, Akita M, and Asakura R contributed to the data analysis and manuscript writing/editing; Arai K, Yoshida T, So S, Ishida J, Urade T, Nanno Y, Fukushima K, Gon H, Komatsu S, Asari S, Toyama H, Kido M, and Ajiki T provided clinical advice; Fukumoto T supervised the report.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Kobe University Graduate School of Medicine (Provided ID Number: B210306).
Informed consent statement: Informed consent was obtained from the opt-out principle. For full disclosure, the details of the study are published on the home page of Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Hiroaki Yanagimoto, MD, PhD, Professor, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan. yanagimh@med.kobe-u.ac.jp
Received: November 6, 2023
Peer-review started: November 6, 2023
First decision: November 22, 2023
Revised: December 5, 2023
Accepted: December 25, 2023
Article in press: December 25, 2023
Published online: January 16, 2024
Processing time: 66 Days and 0.2 Hours
ARTICLE HIGHLIGHTS
Research background
Venous thromboembolism (VTE) after hepatectomy is a potentially fatal complication.
Research motivation
The motivation of this study is that monitoring plasma D-dimer could be useful in the early diagnosis of VTE after hepatectomy.
Research objectives
To uncover the incidence of VTE after hepatectomy without postoperative prophylactic anticoagulant therapy and to investigate the significance of plasma D-dimer monitoring for the early detection and treatment of VTE.
Research methods
This was a retrospective study on the development of VTE after hepatectomy for malignant disease was performed at a single institution over a 3-year period. We compared patients categorized based on the presence or absence of VTE to examine risk factors for the development of postoperative VTE.
Research results
Thirteen (5.6%) patients were diagnosed with VTE following hepatectomy. Elevation of D-dimer on postoperative day 5 and increased intraoperative blood loss were risk factors for the development of VTE after hepatectomy.
Research conclusions
We proposed that monitoring of plasma D-dimer levels after hepatectomy is useful for early diagnosis of VTE, and may avoid routine prophylactic anticoagulation in the postoperative period.
Research perspectives
We demonstrated monitoring D-dimer as an alternative to routine postoperative anticoagulation for early diagnosis of postoperative VTE.
