Lin S, Tang J, Li X, Wu G, Lin YF, Li YF. Mendelian randomization provides evidence for a causal effect of serum insulin-like growth factor family concentration on risk of atrial fibrillation. World J Clin Cases 2023; 11(36): 8475-8485 [PMID: 38188205 DOI: 10.12998/wjcc.v11.i36.8475]
Corresponding Author of This Article
Yi-Fei Li, MD, Professor, Department of Pediatrics and Ministry of Education Key Laboratory of Women and Children's Diseases and Birth Defects, West China Second University Hospital, Sichuan University, No. 20 3rd Section, South Renmin Road, Chengdu 610041, Sichuan Province, China. liyfwcsh@scu.edu.cn
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Evidence-Based Medicine
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 26, 2023; 11(36): 8475-8485 Published online Dec 26, 2023. doi: 10.12998/wjcc.v11.i36.8475
Mendelian randomization provides evidence for a causal effect of serum insulin-like growth factor family concentration on risk of atrial fibrillation
Sha Lin, Jie Tang, Xing Li, Gang Wu, Yi-Fei Lin, Yi-Fei Li
Sha Lin, Jie Tang, Xing Li, Gang Wu, Yi-Fei Li, Department of Pediatrics and Ministry of Education Key Laboratory of Women and Children's Diseases and Birth Defects, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Yi-Fei Lin, Yi-Fei Li, Medical Device Regulatory Research and Evaluation Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Co-corresponding authors: Yi-Fei Li and Gang Wu.
Author contributions: Lin S, Tang J and Li X collected the data; Lin S performed the MR analysis; Wu G, Lin YF and Li YF conceptualized and designed the study, coordinated and supervised data collection, and critically reviewed the manuscript for important intellectual content; Wu G, Lin YF and Li YF were responsible for the revision of the manuscript for important intellectual content; all authors issued final approval for the version to be submitted.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Fei Li, MD, Professor, Department of Pediatrics and Ministry of Education Key Laboratory of Women and Children's Diseases and Birth Defects, West China Second University Hospital, Sichuan University, No. 20 3rd Section, South Renmin Road, Chengdu 610041, Sichuan Province, China. liyfwcsh@scu.edu.cn
Received: October 1, 2023 Peer-review started: October 1, 2023 First decision: November 16, 2023 Revised: November 10, 2023 Accepted: December 7, 2023 Article in press: December 7, 2023 Published online: December 26, 2023 Processing time: 81 Days and 17.4 Hours
ARTICLE HIGHLIGHTS
Research background
The etiology of atrial fibrillation is still unknown, and insulin-like growth factor had been suspected to be involved in atrial fibrillation.
Research motivation
The relationship between insulin-like growth factor and atrial fibrillation had not be well addressed.
Research objectives
This study was carried out to evaluate the causal effect of serum insulin-like growth factor family concentration on risk of atrial fibrillation.
Research methods
Mendelian Randomization analysis was performed based on genome-wide association study datasets of insulin-like growth factor family concentration and atrial fibrillation.
Research results
Lower levels of circulating insulin-like growth factor binding protein 3 was associated with atrial fibrillation.
Research conclusions
The study generated evidence on the potential roles of developmental pathological effects in the pathogenesis of atrial fibrillation.
Research perspectives
Further observational and experimental studies are critically needed.
