Yu KY, Kuang RK, Wu PP, Qiang GH. Subcutaneous fat thickness and abdominal depth are risk factors for surgical site infection after gastric cancer surgery. World J Clin Cases 2023; 11(33): 8013-8021 [PMID: 38075573 DOI: 10.12998/wjcc.v11.i33.8013]
Corresponding Author of This Article
Guang-Hui Qiang, MD, Doctor, Surgeon, Department of Gastrointestinal Surgery, Nanjing Jiangbei Hospital, No. 552 Geguan Road, Jiangbei New District, Nanjing 210044, Jiangsu Province, China. guanghqiang@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Kuan-Yong Yu, Rong-Kang Kuang, Guang-Hui Qiang, Department of Gastrointestinal Surgery, Nanjing Jiangbei Hospital, Nanjing 210044, Jiangsu Province, China
Ping-Ping Wu, Department of Endocrinology, Nanjing Jiangbei Hospital, Nanjing 210044, Jiangsu Province, China
Author contributions: Qiang GH and Yu KY designed the study; Kuang RK drafted the work; Wu PP and Yu KY collected the data; Yu KY and Kuang RK analyzed and interpreted the data; Yu KY and Wu PP wrote the manuscript; Qiang GH and Kuang RK revised the manuscript; all authors read and confirmed the final revision of the manuscript.
Supported byThe Nanjing Health Science and Technology Development Fund Project, No. YKK18241.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of the Nanjing Jiangbei Hospital.
Informed consent statement: The need for informed consent was waived because of the retrospective nature of the study.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guang-Hui Qiang, MD, Doctor, Surgeon, Department of Gastrointestinal Surgery, Nanjing Jiangbei Hospital, No. 552 Geguan Road, Jiangbei New District, Nanjing 210044, Jiangsu Province, China. guanghqiang@126.com
Received: August 14, 2023 Peer-review started: August 14, 2023 First decision: October 9, 2023 Revised: October 19, 2023 Accepted: November 2, 2023 Article in press: November 2, 2023 Published online: November 26, 2023 Processing time: 101 Days and 20 Hours
ARTICLE HIGHLIGHTS
Research background
Surgical site infection (SSI) is one of the most common complications after gastric cancer (GC) surgery. The occurrence of SSI has an adverse impact on the prognosis of patients. There are very few studies that focus on the effect of subcutaneous fat thickness (SFT) and abdominal depth (AD) on postoperative SSI.
Research motivation
In this study, the authors sought to identify ways to assist clinicians in the early identification and treatment of postoperative SSI after GC surgery.
Research objectives
To explore the potential relationship between SFT or AD and SSI in patients after elective radical resection of GC.
Research methods
Demographic, clinical, and pre- and intraoperative information of 355 patients who had undergone elective radical resection of GC were retrospectively collected from hospital electronic medical records. Univariate and multivariate logistic regression analyses were used to screen for the risk factors contributing to SSI incidence. Furthermore, the receiver-operating characteristic (ROC) curve method was employed to evaluate the predictive power and best cutoff value for the biomarkers under consideration.
Research results
The prevalence of SSI was 11.27% (40/355). Multivariate analyses revealed that SFT, AD, laparoscopic-assisted surgery, and operation time were independently associated with the incidence of SSI after elective radical resection of GC. The area under the ROC curve values of SFT, AD, and the product of SFT and AD (SFT × AD) were 0.770 [95% confidence interval (95%CI): 0.700–0.839], 0.715 (95%CI: 0.635–0.795), and 0.810 (95%CI: 0.740–0.879), respectively.
Research conclusions
Our results suggest that preoperative SFT, AD, and operation time are independent risk factors for SSI after GC surgery, while laparoscopic-assisted surgery is a protective factor. In addition, SFT × AD is a better potential predictor of SSI in these patients than either SFT or AD alone.
Research perspectives
In the future, we will increase the sample size used to construct the model and conduct a multicenter study.
