Yamazato M, Yanai S, Oizumi T, Eizuka M, Yamada S, Toya Y, Uesugi N, Sugai T, Matsumoto T. Appropriate leucine-rich α-2 glycoprotein cut-off value for Japanese patients with ulcerative colitis. World J Clin Cases 2023; 11(32): 7753-7760 [PMID: 38073694 DOI: 10.12998/wjcc.v11.i32.7753]
Corresponding Author of This Article
Shunichi Yanai, Doctor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, 2-1-1 Idaidori, Yahaba 028-3695, Japan. syanai@iwate-med.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Masanao Yamazato, Shunichi Yanai, Tomofumi Oizumi, Makoto Eizuka, Shun Yamada, Yosuke Toya, Takayuki Matsumoto, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3695, Japan
Noriyuki Uesugi, Tamotsu Sugai, Division of Molecular Diagnostic Pathology, Iwate Medical University, Yahaba 028-3695, Japan
Author contributions: Yamazato M, and Yanai S performed the conception and design; Yamazato M, Yanai S, Oizumi T, Eizuka M, Yamada S, Toya Y, Uesugi N, and Sugai T performed the data collection; Yamazato M, and Yanai S contributed to the data analysis and statistical analysis; The first draft of manuscript was written by Yamazato M, and Yanai S; Matsumoto T critically reviewed and revised the manuscript; All authors read and approved the final manuscript for submission.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Iwate Medical University Hospital.
Informed consent statement: Patients were not required to give informed consent as this is a retrospective study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shunichi Yanai, Doctor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, 2-1-1 Idaidori, Yahaba 028-3695, Japan. syanai@iwate-med.ac.jp
Received: May 22, 2023 Peer-review started: May 22, 2023 First decision: August 8, 2023 Revised: August 18, 2023 Accepted: November 2, 2023 Article in press: November 2, 2023 Published online: November 16, 2023 Processing time: 177 Days and 18.1 Hours
ARTICLE HIGHLIGHTS
Research background
Serum leucine-rich α-2 glycoprotein (LRG) can be used for the assessment of disease activity in ulcerative colitis (UC). However, practical cut-off values of LRG for remission have not been established in patients with UC.
Research motivation
LRG cut-off value for remission will lessen the need for colonoscopy.
Research objectives
To establish cut-off values of LRG for endoscopic and histological remission in UC.
Research methods
We retrospectively analyzed the relationship between LRG and clinical, endoscopic and histologic activities in patients with UC.
Research results
In 30 patients, the correlations between LRG value and Mayo Endoscopic Subscore (MES) or UC Endoscopic Index of Severity (UCEIS) were significant (r = 0.754, P < 0.0001; r = 0.778, P < 0.0001, respectively). Significant correlations were also found between CRP level and MES or UCEIS (r = 0.599, P = 0.0005; r = 0.563, P = 0.0012, respectively); however, the correlation coefficients were higher for LRG value. The LRG cut-off value for predicting endoscopic remission was 13.4 μg/mL for an MES of 0 [area under the curve (AUC): 0.871, 95% confidence interval (CI): 0.744–0.998], and 13.4 μg/mL for a UCEIS of 0 or 1 (AUC: 0.904; 95%CI: 0.792–1.000).
Research conclusions
LRG can be applied to the prediction of endoscopic and histological remission in UC.
Research perspectives
Further prospective studies are deemed to validate our findings.
