Published online Nov 6, 2023. doi: 10.12998/wjcc.v11.i31.7610
Peer-review started: September 19, 2023
First decision: September 28, 2023
Revised: October 7, 2023
Accepted: October 26, 2023
Article in press: October 26, 2023
Published online: November 6, 2023
Processing time: 48 Days and 0.7 Hours
The combination of inhaled corticosteroids (ICS) and long-acting β2 receptor agonist (LABA), such as salmeterol, can provide a more effective treatment strategy, but there is a lack of comprehensive research and evaluation on the efficacy of salmeterol combined with budesonide in the treatment of cough variant asthma (CVA) in children.
To systematically explore the efficacy of LABA salmeterol combined with ICS budesonide in the treatment of CVA in children, and to provide some clinical treatment suggestions for the treatment and clinical recovery of CVA in children.
The purpose of this study is to systematically evaluate the efficacy of LABA salmeterol combined with ICS budesonide in the treatment of CVA in children, and to explore the influence of the combination of the two drugs on the clinical efficacy and recovery index of asthma control in children.
Children with CVA were selected prospectively and randomly divided into observation group (salmeterol combined with budesonide) and control group (budesonide combined with placebo). The clinical efficacy and immune function markers of the two groups were compared.
After treatment, the effect and efficiency of the two groups were improved to some extent. The symptoms of CVA in the treatment group were relieved, and the lung function index and immune marker level were also better than those in the control group.
Both salmeterol combined with budesonide and budesonide alone can treat CVA to a certain extent, but the therapeutic effect of the former is significantly higher than that of the latter in symptom improvement, immune marker level and lung function level.
Salmeterol combined with budesonide is an effective method to treat CVA disease, which is worth popularizing in clinic.