Chen CH, Wang CK, Wang CY, Chang CF, Chu TW. Roles of biochemistry data, lifestyle, and inflammation in identifying abnormal renal function in old Chinese. World J Clin Cases 2023; 11(29): 7004-7016 [PMID: 37946770 DOI: 10.12998/wjcc.v11.i29.7004]
Corresponding Author of This Article
Ta-Wei Chu, MD, PhD, CEO, Chief Physician, Doctor, Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, No. 325 Sec. 2, Chenggong Road, Neihu District, Taipei 114, Taiwan. david_chu@mjlife.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Chao-Hung Chen, Chun-Feng Chang, Division of Urology, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan
Chao-Hung Chen, Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Keelung 204, Taiwan
Chun-Kai Wang, Department of Obstetrics and Gynecology, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813, Taiwan
Chen-Yu Wang, Ta-Wei Chu, Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Chun-Feng Chang, Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Ta-Wei Chu, Chief Executive Officer's Office, MJ Health Research Foundation, Taipei 114, Taiwan
Author contributions: Chen CH participated in the design and oversight of the study, and was involved in data collection; Wang CK participated in the design of the study and was involved in data collection; Wang CY was involved in data collection and assisted with data analysis; Chang CF drafted the manuscript and assisted with data analysis; Chu TW drafted the manuscript and assisted with data analysis; all authors read and approved the final manuscript.
Supported bythe Kaohsiung Armed Forces General Hospital.
Institutional review board statement: The study protocol was approved by the Institutional Review Board of the Tri-Service General Hospital, National Defense Medical Center (IRB No.: KAFGHIRB 109-46).
Informed consent statement: All study participants, or their legal guardian, provided written consent prior to study enrollment.
Conflict-of-interest statement: All the authors of this manuscript have no conflicts of interest to disclose.
Data sharing statement: There is no additional data available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ta-Wei Chu, MD, PhD, CEO, Chief Physician, Doctor, Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, No. 325 Sec. 2, Chenggong Road, Neihu District, Taipei 114, Taiwan. david_chu@mjlife.com
Received: July 5, 2023 Peer-review started: July 5, 2023 First decision: July 18, 2023 Revised: August 1, 2023 Accepted: September 11, 2023 Article in press: September 11, 2023 Published online: October 16, 2023 Processing time: 94 Days and 6.5 Hours
ARTICLE HIGHLIGHTS
Research background
The incidence of chronic kidney disease (CKD) has significantly increased in recent years, leading to substantial impacts on patient mortality rates.
Research motivation
Previous studies have identified various risk factors for CKD, but they mostly relied on traditional statistical methods, such as logistic regression, and focused only on a limited number of risk factors.
Research objectives
To evaluate the impact of lifestyle and chronic inflammation in identifying subjects with abnormal estimated glomerular rates among elderly Chinese elderly subjects.
Research methods
The main focus of this study is to utilize five machine learning methods (Mach-L) for identifying factors.
Research results
Our results showed that uric acid is the most important risk factor (inflammatory marker), followed by age, hemoglobin, body mass index, sport hours, and systolic blood pressure.
Research conclusions
The study highlights that among demographic, biochemistry, lifestyle risk factors, and inflammation markers, UA is the most crucial risk factor for identifying low estimated glomerular filtration rate in elderly Chinese individuals, followed by age, hemoglobin, body mass index, sport hours, and systolic blood pressure.
Research perspectives
Further longitudinal studies are warranted to validate and clarify the causal relationships between these factors and estimated glomerular filtration rate changes.
