Choi HJ, Lee JH, Jung CS, Ryu JM, Chae BJ, Lee SK, Yu JH, Kim SW, Nam SJ, Lee JE, Jung YJ, Kim HY. Oncologic efficacy of gonadotropin-releasing hormone agonist in hormone receptor-positive very young breast cancer patients treated with neoadjuvant chemotherapy. World J Clin Cases 2023; 11(27): 6398-6406 [PMID: 37900220 DOI: 10.12998/wjcc.v11.i27.6398]
Corresponding Author of This Article
Hyun Yul Kim, MD, PhD, Associate Professor, Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Beomeo-ri, Mulgeum-eup, Yangsan-si, Gyeongnam 50612, South Korea. isepa102@naver.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 26, 2023; 11(27): 6398-6406 Published online Sep 26, 2023. doi: 10.12998/wjcc.v11.i27.6398
Oncologic efficacy of gonadotropin-releasing hormone agonist in hormone receptor-positive very young breast cancer patients treated with neoadjuvant chemotherapy
Hee Jun Choi, Jun Ho Lee, Chang Shin Jung, Jai Min Ryu, Byung Joo Chae, Se Kyung Lee, Jong Han Yu, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee, Youn Joo Jung, Hyun Yul Kim
Hee Jun Choi, Jun Ho Lee, Chang Shin Jung, Department of Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, South Korea
Jai Min Ryu, Byung Joo Chae, Se Kyung Lee, Jong Han Yu, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee, Division of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, South Korea
Youn Joo Jung, Hyun Yul Kim, Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Gyeongnam 50612, South Korea
Author contributions: Choi HJ is the first author, planed and wrote this manuscript; all played a role in the data organization and modulation of this article; Kim HY planed, revised, edited and submitted this article.
Institutional review board statement: This study was approved by the Institutional Review Board of the Samsung Medical Center, Seoul, Korea (IRB file No. 2017-12-118-002). To protect personal information, patient records and information were anonymized and identities were removed prior to analysis.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: Dataset available from the corresponding author at isepa102@naver.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hyun Yul Kim, MD, PhD, Associate Professor, Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Beomeo-ri, Mulgeum-eup, Yangsan-si, Gyeongnam 50612, South Korea. isepa102@naver.com
Received: June 23, 2023 Peer-review started: June 23, 2023 First decision: July 4, 2023 Revised: July 17, 2023 Accepted: August 25, 2023 Article in press: August 25, 2023 Published online: September 26, 2023 Processing time: 88 Days and 19.6 Hours
ARTICLE HIGHLIGHTS
Research background
There are many younger breast cancer patients in Korea than in the West, and they are known to have a poor prognosis.
Research motivation
To improve the prognosis of hormone receptor (HR) positive young breast cancer patients.
Research objectives
To investigate the efficacy of gonadotropin-releasing hormone (GnRH) agonist treatment in HR positive young breast cancer patients.
Research methods
We analyzed the characteristics and oncology outcomes between the equal-to-or-younger-than-35-years group (n = 78) and the older-than-35-years group (n = 353).
Research results
GnRH agonist was more significantly used in patients younger than 35 years old than in patients older than 35 years (52.4% vs 11.2%, P < 0.001).
Research conclusions
The GnRH agonists might improve the disease free survival outcome of HR-positive/HER2-negative breast cancer patients.
Research perspectives
Administration of GnRH agonist with anti-hormonenal therapy is helpful in young breast cancer patients.
