Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 16, 2023; 11(23): 5440-5446
Published online Aug 16, 2023. doi: 10.12998/wjcc.v11.i23.5440
Application effect of phloroglucinol injection in elderly patients with spastic abdominal pain in emergency department
Yu-Fei Liu, Jian Chen
Yu-Fei Liu, Jian Chen, Emergency Medicine Department, Hefei BOE Hospital, Hefei 230000, Anhui Province, China
Author contributions: Liu YF and Chen J contributed equally to this work; Liu YF designed the study; Chen J contributed to the analysis of the manuscript; Liu YF and Chen J involved in the data and writing of this article; and all authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Hefei BOE Hospital.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that there are no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian Chen, Doctor, Associate Chief Physician, Master’s Student, Emergency Medicine Department, Hefei BOE Hospital, Northwest of the Intersection of Dongfang Avenue and Wenzhong Road, Yaohai District, Hefei 230000, Anhui Province, China. 2670260592@qq.com
Received: June 14, 2023
Peer-review started: June 14, 2023
First decision: June 21, 2023
Revised: June 29, 2023
Accepted: July 25, 2023
Article in press: July 25, 2023
Published online: August 16, 2023
ARTICLE HIGHLIGHTS
Research background

Drugs for elderly patients with spasmodic abdominal pain must be selected carefully to avoid adverse reactions. Alternative treatments are required for safe and effective management of spasmodic abdominal pain.

Research motivation

To address the requirement for safe and effective alternative treatments for elderly patients with spasmodic abdominal pain, because drug selection is critical for avoiding adverse reactions in this vulnerable population.

Research objectives

To determine the safety and effectiveness of mebendazole injection as an alternative treatment for the emergency management of spasmodic abdominal pain, while minimizing adverse reactions, in elderly patients. The study establishes a valuable treatment option that accelerates symptom disappearance and improves clinical activity in this vulnerable population.

Research methods

The study investigated 112 elderly patients with spasmodic abdominal pain admitted to the hospital from July 2021 to June 2022. A control group (n = 56 patients) received intravenous tolopin from January 2021 to December 2021, while the experimental group (n = 56 patients) received mebendazole injection from June 2022 to June 2022. Both groups were treated for 3 days. Clinical symptoms and adverse reactions were observed before and after the treatment to compare the differences in symptom disappearance time and adverse reactions between the two groups.

Research results

Mebendazole injection had a higher therapeutic effect and led to faster symptom disappearance in elderly patients with spasmodic abdominal pain than traditional treatments.

Research conclusions

Mebendazole injection is a safe and effective treatment option for elderly patients with spasmodic abdominal pain in emergency situations. It can accelerate clinical symptom disappearance, reduce the stomach weight, and improve clinical activity. Mebendazole injection can potentially be applied as a valuable treatment option that is safe for use in this vulnerable population.

Research perspectives

Future studies should focus on the long-term safety and effectiveness of mebendazole injection in elderly patients with spasmodic abdominal pain.