Ege F, Kazci Ö, Aydin S. Diabetic neuropathy results in vasomotor dysfunction of medium sized peripheral arteries. World J Clin Cases 2023; 11(22): 5244-5251 [PMID: 37621590 DOI: 10.12998/wjcc.v11.i22.5244]
Corresponding Author of This Article
Sonay Aydin, MD, PhD, Academic Editor, Academic Research, Associate Professor, Department of Radiology, Erzincan Binali Yıldırım University Faculty of Medicine, Mengücek, Erzincan 063200, Turkey. sonay.aydin@erzincan.edu.tr
Research Domain of This Article
Medicine, General & Internal
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 6, 2023; 11(22): 5244-5251 Published online Aug 6, 2023. doi: 10.12998/wjcc.v11.i22.5244
Diabetic neuropathy results in vasomotor dysfunction of medium sized peripheral arteries
Fahrettin Ege, Ömer Kazci, Sonay Aydin
Fahrettin Ege, Department of Neurology, VM Medicalpark Hospital, Ankara 063200, Turkey
Ömer Kazci, Department of Radiology, Ankara Training and Research Hospital, Ankara 063200, Turkey
Sonay Aydin, Department of Radiology, Erzincan Binali Yıldırım University Faculty of Medicine, Erzincan 063200, Turkey
Author contributions: Fahrettin EGE and Omer Kazci contributed equally to this work; Sonay Aydin designed the research study; Omer Kazci analyzed the data and wrote the manuscript; All authors have read and approved the final manuscript.
Institutional review board statement: This study adhered to the most recent version of the Declaration of Helsinki, and the No. 2 Clinical Research Ethics Committee of Ankara City Hospital allowed the procedures. The ethics committee at Ankara City Hospital is the most approved ethics body within the Turkish Ministry of Health. Due to the nature and significance of our research, we deemed it necessary to obtain ethical approval from Ankara City Hospital (Approval number: E3-22-1307).
Informed consent statement: Each participant and/or guardian gave informed consent(s).
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sonay Aydin, MD, PhD, Academic Editor, Academic Research, Associate Professor, Department of Radiology, Erzincan Binali Yıldırım University Faculty of Medicine, Mengücek, Erzincan 063200, Turkey. sonay.aydin@erzincan.edu.tr
Received: March 29, 2023 Peer-review started: March 29, 2023 First decision: June 1, 2023 Revised: June 6, 2023 Accepted: July 3, 2023 Article in press: July 3, 2023 Published online: August 6, 2023 Processing time: 126 Days and 15.5 Hours
ARTICLE HIGHLIGHTS
Research background
When the smooth muscle cells lining blood vessels contract in response to stimulation from the sympathetic nervous system, the result is vasoconstriction and a decrease in blood flow to the extremities.
Research motivation
To identify a different method for the detection of diabetic autonomic neuropathy that does not impair patient comfort.
Research objectives
The goal of this research was to determine whether there is major vasomotor dysfunction of medium-sized arteries in diabetic neuropathy by comparing the sympathetic vasomotor activation of the brachial arteries in healthy people and patients with painful diabetic neuropathy.
Research methods
A 10 mA, 1 Hz electrical stimulus was applied to the median nerve in the wrist for 5 s using a bipolar stimulus electrode. Following stimulation, the diameter of the brachial artery and the blood flow rate were re-measured.
Research results
In the control group, the median flow rate was 70.0 mL/min prior to stimulation and 35.0 mL/min after stimulation, with a statistically significant decrease (P < 0.001) which is consistent with sympathetic nervous system functioning (vasoconstriction). In the diabetic neuropathy group, median flow rate before stimulation was 35.0 mL/min. After stimulation, the median flow rate was 77.0 mL/min; thus, no significant decrease in the flow rate was detected. In the control group, the median brachial artery diameter, which was 3.6 mm prior to stimulation, decreased to 3.4 mm after stimulation, and this decrease was also statistically significant (P = 0.046). In the diabetic neuropathy group, the median brachial artery diameter increased from 3.4 mm to 3.6 mm following nerve stimulation. Once again, no narrowing was observed.
Research conclusions
Our study shows that diabetic neuropathy causes medium-sized peripheral arteries to have blood flow problems. In diabetic neuropathy, the body cannot constrict blood vessels normally when the sympathetic nervous system is activated.
Research perspectives
We will try this new method in the clinic in the future.
