Zhu MY, Tang XK, Gao Y, Xu JJ, Gong YQ. Impact of heart failure on outcomes in patients with sepsis: A systematic review and meta-analysis. World J Clin Cases 2023; 11(15): 3511-3521 [PMID: 37383893 DOI: 10.12998/wjcc.v11.i15.3511]
Corresponding Author of This Article
Yuan-Qi Gong, MD, PhD, Professor, Department of the Intensive Care Unit, The Second Affiliated Hospital of Nanchang University, No. 1 Demin Road, Donghu District, Nanchang 330006, Jiangxi Province, China. 760225787@qq.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. May 26, 2023; 11(15): 3511-3521 Published online May 26, 2023. doi: 10.12998/wjcc.v11.i15.3511
Impact of heart failure on outcomes in patients with sepsis: A systematic review and meta-analysis
Ming-Yu Zhu, Xiao-Kai Tang, Yi Gao, Jing-Jing Xu, Yuan-Qi Gong
Ming-Yu Zhu, Yi Gao, Jing-Jing Xu, Yuan-Qi Gong, Department of the Intensive Care Unit, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Xiao-Kai Tang, Department of the Orthopaedic, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Author contributions: Zhu MY conceived the study and wrote the paper; Tang XK and Xu JJ performed literature search and data collection; Gao Y designed the study and analyzed the data; Gong YQ revised the study and paper; all authors read and approved the final manuscript.
Supported byThe National Natural Science Foundation of China, No. 8186080205 and No. 8226080303.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yuan-Qi Gong, MD, PhD, Professor, Department of the Intensive Care Unit, The Second Affiliated Hospital of Nanchang University, No. 1 Demin Road, Donghu District, Nanchang 330006, Jiangxi Province, China. 760225787@qq.com
Received: February 7, 2023 Peer-review started: February 7, 2023 First decision: February 28, 2023 Revised: March 6, 2023 Accepted: April 6, 2023 Article in press: April 6, 2023 Published online: May 26, 2023 Processing time: 107 Days and 6.8 Hours
ARTICLE HIGHLIGHTS
Research background
Sepsis is one of the main causes of death in the intensive care unit and hospitals. Sepsis patients often have heart failure. However, the impact of heart failure on the mortality of sepsis patients is controversial.
Research motivation
Although the treatment of sepsis has been updated, the effect of heart failure on the outcome of patients with sepsis still requires further study. Understanding whether heart failure, as a comorbidity, will affect the survival of patients with sepsis is significant in order to take appropriate measures to reduce the occurrence of adverse results.
Research objectives
The purpose of our study was to assess whether heart failure increases the mortality of patients with sepsis by collecting existing research evidence.
Research methods
PubMed, Embase, Web of Science, and Cochrane Library databases from inception to November 9, 2022 were searched to compare the prognosis of sepsis patients with heart failure. The outcome data were summarized in the random effect model using odds ratio (OR) and 95% confidence interval (CI).
Research results
Ten studies were included. The results showed that sepsis patients with heart failure were associated with increased total mortality (OR = 1.80, 95%CI: 1.34-2.43; I2 = 92.1%). Heart failure did not increase the 1-year mortality of patients (OR = 1.11, 95%CI: 0.75-1.62; I2 = 93.2%), and the mortality of patients with isolated right ventricular dysfunction (OR = 2.32, 95%CI: 1.29-4.14; I2 = 91.5%) increased significantly.
Research conclusions
Contemporary evidence indicates that heart failure significantly increases the risk of death in patients with sepsis, especially right ventricular dysfunction.
Research perspectives
Sepsis patients with heart failure should receive highly monitored treatment, and more high-quality related research is needed.
