Bogdanova I, Polaka I, Aleksandraviča I, Dzērve Z, Anarkulova L, Novika V, Tolmanis I, Leja M. Role of pre-existing incomplete intestinal metaplasia in gastric adenocarcinoma: A retrospective case series analysis. World J Clin Cases 2023; 11(12): 2708-2715 [PMID: 37214563 DOI: 10.12998/wjcc.v11.i12.2708]
Corresponding Author of This Article
Marcis Leja, AGAF, MD, PhD, Academic Editor, Director, Professor, Researcher, Institute of Clinical and Preventive Medicine, University of Latvia, 1 Gaiļezera Iela, Riga LV1079, Latvia. marcis.leja@lu.lv
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Apr 26, 2023; 11(12): 2708-2715 Published online Apr 26, 2023. doi: 10.12998/wjcc.v11.i12.2708
Role of pre-existing incomplete intestinal metaplasia in gastric adenocarcinoma: A retrospective case series analysis
Inga Bogdanova, Inese Polaka, Ilona Aleksandraviča, Zane Dzērve, Linda Anarkulova, Vita Novika, Ivars Tolmanis, Marcis Leja
Inga Bogdanova, Department of Pathology, Academic Histology Laboratory, Riga LV1073, Latvia
Inga Bogdanova, Inese Polaka, Ilona Aleksandraviča, Zane Dzērve, Linda Anarkulova, Marcis Leja, Institute of Clinical and Preventive Medicine, University of Latvia, Riga LV1079, Latvia
Ilona Aleksandraviča, Marcis Leja, Department of Research, Riga East University Hospital, Riga LV1079, Latvia
Zane Dzērve, Vita Novika, Ivars Tolmanis, Department of Endoscopy, Digestive Diseases Centre GASTRO, Riga LV1079, Latvia
Marcis Leja, Department of Gastroenterology, Digestive Diseases Centre GASTRO, Riga LV1079, Latvia
Author contributions: Bogdanova I designed the outline and performed all the pathology evaluation, including specific staining for intestinal metaplasia subtypes, performed the analysis of the obtained results and design of the tables; Aleksandraviča I coordinated the biobanking activities and data acquisition; Tolmanis I reviewed the endoscopy reports; Leja M coordinated the research and participated in the outline design and writing of the paper, all authors were involved in writing and final approval of the manuscript.
Institutional review board statement: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Medical and Biomedical Research Ethics Committee of the Riga East University Hospital Support Foundation, protocol 18-A/16, October 6, 2016.
Informed consent statement: Signed consent was obtained form all the study subjects at the time of their recruitment to the Biobank.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other co-authors contributed their efforts in this manuscript.
Data sharing statement: No additional data available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marcis Leja, AGAF, MD, PhD, Academic Editor, Director, Professor, Researcher, Institute of Clinical and Preventive Medicine, University of Latvia, 1 Gaiļezera Iela, Riga LV1079, Latvia. marcis.leja@lu.lv
Received: December 27, 2022 Peer-review started: December 27, 2022 First decision: January 5, 2023 Revised: January 19, 2023 Accepted: March 29, 2023 Article in press: March 29, 2023 Published online: April 26, 2023 Processing time: 119 Days and 5.1 Hours
ARTICLE HIGHLIGHTS
Research background
Gastric cancer is still remaining an important burden of the global health. Proper stratification of precancerous lesions is of significant importance for scheduling surveillance endoscopic investigations.
Research motivation
To address the role of intestinal metaplasia subtyping in clinical settings.
Research objectives
To investigate the subtypes of intestinal metaplasia during an endoscopy that was performed prior to cancer development in a retrospective cohort.
Research methods
Retrospective analysis of patients having been diagnosed with gastric cancer following a past endoscopic assessment (without cancer).
Research results
Incomplete type intestinal metaplasia was present in all patients having developed cancer. In all three patients in whom the subtyping of intestinal metaplasia was performed according to Filipe et al, Type III intestinal metaplasia was present.
Research conclusions
Subtyping of gastric intestinal metaplasia is important for clinical practice.
Research perspectives
Larger-scale case-controlled studies would be required to support the conclusions.
