Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 26, 2022; 10(9): 2764-2772
Published online Mar 26, 2022. doi: 10.12998/wjcc.v10.i9.2764
Enucleation combined with guided bone regeneration in small and medium-sized odontogenic jaw cysts
Yi-Ting Cao, Qin-Hua Gu, Yi-Wei Wang, Qian Jiang
Yi-Ting Cao, Department of Pediatric Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
Qin-Hua Gu, Department of Stomatology, Shanghai Ninth People’s Hospital Huangpu Branch, Shanghai Jiao Tong University, School of Medicine, Shanghai 200125, China
Yi-Wei Wang, Department of Oral Medicine, Huai’an Stomatological Hospital, Huai’an 223300, Jiangsu Province, China
Qian Jiang, Department of Oral Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
Author contributions: Jiang Q designed and performed the research and wrote the paper; Cao YT performed the research and wrote the paper; Gu QH and Wang YW performed the research.
Supported by the National Natural Science Foundation of China, No. 31800816; Fundamental Research Program Funding of the Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. JYZZ109.
Institutional review board statement: The study was reviewed and approved by the [Ethics Committee of the Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine] Institutional Review Board [Approval No. SH9H-2020-T391-1].
Informed consent statement: All involved patients gave their informed consent written prior to study inclusion.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qian Jiang, MD, PhD, Attending Doctor, Department of Oral Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, No. 639 Zhizhaoju Road, Shanghai 200011, China. jiangqian720@163.com
Received: August 26, 2021
Peer-review started: August 26, 2021
First decision: November 17, 2021
Revised: November 26, 2021
Accepted: February 19, 2022
Article in press: February 19, 2022
Published online: March 26, 2022
Processing time: 208 Days and 12.4 Hours
ARTICLE HIGHLIGHTS
Research background

The odontogenic jaw cyst is a cavity containing liquid, semifluid or gaseous components, with the development of the disease. In recent years, with the rapid development of oral materials and the transformation of treatment of jaw cysts, more options are available for treatment of postoperative bone defect of jaw cysts. Guided bone regeneration (GBR) places biomaterials in the bone defect, and then uses biofilm to separate the proliferative soft tissue and the slow-growing bone tissue to maintain the space for bone regeneration, which is widely used in the field of implantology.

Research motivation

This was a retrospective study to observe the clinical effect of guided bone regeneration (GBR) in repairing bone defect after enucleation of small and medium-sized odontogenic jaw cysts. The application of odontogenic jaw cysts extraction combined with GBR can shorten the time of osteogenesis, increase the amount of new bone formation, reduce complications, and improve quality of life. GBR has good prospects for application in the treatment of small and medium-sized odontogenic jaw cysts.

Research objectives

To observe the clinical effect of GBR in repairing bone defect after enucleation of small and medium-sized odontogenic jaw cysts.

Research methods

From June 2018 to September 2020, 13 patients (7 male, 6 female) with odontogenic jaw cysts were treated in the Department of Oral Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine. Adults without hypertension, heart disease, diabetes or other systemic diseases were selected. The diagnosis was based on the final pathological results: 11 cases were diagnosed as apical cysts, one as primordial cyst, and one as dentigerous cyst. The lesions were located in the maxilla in seven cases, and in the mandible in six cases. All cases were treated with the same method of enucleation combined with GBR.

Research results

Three to four months after the operation, the boundary between the implant site and the surrounding normal stroma was not obvious in patients with small-sized odontogenic jaw cysts. The patients with tooth defects were treated with implant after 6 mo. For the patients with medium-sized odontogenic jaw cysts, the density of the center of the implant area was close to the normal mass at 6 mo after surgery, and there was a clear boundary between the periphery of the implant area and the normal mass. The boundary between the periphery of the implant area and the normal mass was blurred at 8-9 mo after surgery. Patients with tooth defects were treated with implants at > 6 mo after the operation.

Research conclusions

Enucleation combined with guided bone regeneration in small and medium-sized odontogenic jaw cysts can shorten the time of osteogenesis, increase the amount of new bone formation, reduce complications, and improve quality of life.

Research perspectives

The application of odontogenic jaw cysts extraction combined with GBR can shorten the time of osteogenesis, increase the amount of new bone formation, reduce complications, and improve quality of life. It has good prospects for application in the treatment of odontogenic jaw cysts.