Huang ZY, Liu Y, Huang HF, Huang SH, Wang JX, Tian JF, Zeng WX, Lv RG, Jiang S, Gao JL, Gao Y, Yu XX. Acute kidney injury in traumatic brain injury intensive care unit patients. World J Clin Cases 2022; 10(9): 2751-2763 [PMID: 35434091 DOI: 10.12998/wjcc.v10.i9.2751]
Corresponding Author of This Article
Xia-Xia Yu, PhD, Assistant Professor, School of Biomedical Engineering, Health Science Center, Shenzhen University, No. 1066 Xueyuan Avenue, Nanshan District, Shenzhen 518037, Guangdong Province, China. xiaxiayu@szu.edu.cn
Research Domain of This Article
Neurosciences
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Zheng-Yang Huang, Hao-Fan Huang, Shu-Hua Huang, Yi Gao, Xia-Xia Yu, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518037, Guangdong Province, China
Yong Liu, Jing-Xin Wang, Jin-Fei Tian, Wen-Xian Zeng, Rong-Gui Lv, Song Jiang, Intensive Care Unit, Shenzhen Hospital, Southern Medical University, Shenzhen 518101, Guangdong Province, China
Jun-Ling Gao, Department of Medicine, LKS Medical Faculty, The University of Hong Kong, Hongkong 999077, China
Author contributions: Yu XX and Liu Y conceived and coordinated the study, designed, performed and analyzed the experiments, wrote the paper; Wang JX, Tian JF, Zeng WX, Jiang S and Lv RG carried out the data collection and preprocess of the raw data; Huang ZY, Huang HF and Huang SH performed the data analysis; Liu Y and Gao JL revised the paper; all authors reviewed the results and approved the final version of the manuscript.
Institutional review board statement: The study was approved by the Ethics Committee for Human Research of Shenzhen Hospital, Southern Medical University, No. YS2YYEC20180009.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xia-Xia Yu, PhD, Assistant Professor, School of Biomedical Engineering, Health Science Center, Shenzhen University, No. 1066 Xueyuan Avenue, Nanshan District, Shenzhen 518037, Guangdong Province, China. xiaxiayu@szu.edu.cn
Received: August 11, 2021 Peer-review started: August 11, 2021 First decision: October 20, 2021 Revised: November 30, 2021 Accepted: February 12, 2022 Article in press: February 12, 2022 Published online: March 26, 2022 Processing time: 223 Days and 10.5 Hours
ARTICLE HIGHLIGHTS
Research background
Early identification and subsequent clinical intervention of acute kidney injury (AKI) in traumatic brain injury (TBI) patients are critical to survival.
Research motivation
The exact definition of AKI for patients with TBI is unknown.
Research objectives
We aimed to compare four AKI diagnostic criteria to determine AKI incidence/stage and their association with the in-hospital mortality rate of patients with TBI.
Research methods
The subjects in this study were assessed for the presence and stage of AKI using four different AKI diagnostic criteria.
Research results
The in-hospital mortality rates increased with the AKI stage in all four definitions. The severity of AKI by all definitions and stages was not associated with in-hospital mortality in the multivariable analyses (all P > 0.05).
Research conclusions
This study revealed that Kidney Disease Improving Global Outcomes (KDIGO) is the best method to define AKI in patients with TBI.
Research perspectives
In the future, it is necessary to increase the sample size for prospective studies to further explore.
