Li Y, Li DB, Zhao LD, Lv QB, Wang Y, Ren YF, Zhang WB. Effects of bilirubin on perioperative myocardial infarction and its long-term prognosis in patients undergoing percutaneous coronary intervention. World J Clin Cases 2022; 10(6): 1775-1786 [PMID: 35317137 DOI: 10.12998/wjcc.v10.i6.1775]
Corresponding Author of This Article
Wen-Bin Zhang, MD, Associate Chief Physician, Associate Professor, Department of Cardiovascular Diseases, Sir Run Run Shaw Hospital, College of Medicine of Zhejiang University, No. 3 Qinchundong Road, Hangzhou 310016, Zhejiang Province, China. 3313011@zju.edu.cn
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 26, 2022; 10(6): 1775-1786 Published online Feb 26, 2022. doi: 10.12998/wjcc.v10.i6.1775
Effects of bilirubin on perioperative myocardial infarction and its long-term prognosis in patients undergoing percutaneous coronary intervention
Ya Li, Duan-Bin Li, Li-Ding Zhao, Qing-Bo Lv, Yao Wang, Ya-Fei Ren, Wen-Bin Zhang
Ya Li, Duan-Bin Li, Li-Ding Zhao, Qing-Bo Lv, Yao Wang, Wen-Bin Zhang, Department of Cardiovascular Diseases, Sir Run Run Shaw Hospital, College of Medicine of Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Ya-Fei Ren, Department of Rehabilitation Medicine, Qilu Institute of Technology, Jinan 250200, Shandong Province, China
Author contributions: Li Y and Li DB reviewed the literature and contributed to manuscript drafting; Lv QB, Wang Y, Zhao LD and Ren YF contributed to data collection, interpretation, and analysis; Zhang WB was responsible for revision of the manuscript for important intellectual content; all authors issued final approval for the version to be submitted.
Institutional review board statement: The study was reviewed and approved by Sir Run Run Shaw Hospital.
Conflict-of-interest statement: All authors have nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Bin Zhang, MD, Associate Chief Physician, Associate Professor, Department of Cardiovascular Diseases, Sir Run Run Shaw Hospital, College of Medicine of Zhejiang University, No. 3 Qinchundong Road, Hangzhou 310016, Zhejiang Province, China. 3313011@zju.edu.cn
Received: September 8, 2021 Peer-review started: September 8, 2021 First decision: October 27, 2021 Revised: November 14, 2021 Accepted: January 11, 2022 Article in press: January 11, 2022 Published online: February 26, 2022 Processing time: 168 Days and 8.9 Hours
ARTICLE HIGHLIGHTS
Research background
As a frequent complication of percutaneous coronary intervention (PCI), the rate of perioperative myocardial infarction (PMI) remains high and patients suffering from PMI have poor outcomes.
Research motivation
To identify whether bilirubin could be a potential target for PMI avoidance.
Research objectives
To explore the impact of bilirubin levels on PMI and long-term prognosis in post-PMI patients.
Research methods
Logistic regression and Cox regression analyses were used to explore the association between bilirubin, PMI and its long-term prognosis.
Research results
Higher bilirubin was associated with a reduced rate of PMI and major adverse cardiovascular events.
Research conclusions
Bilirubin was a protective factor in PMI prediction and produced a better long-term prognosis in post-PMI patients.
Research perspectives
The study provides evidence of bilirubin as a therapeutic target in PMI prevention.
