Zhang LP, Zhang XX. Relationship between lipids and sleep apnea: Mendelian randomization analysis. World J Clin Cases 2022; 10(31): 11403-11410 [PMID: 36387818 DOI: 10.12998/wjcc.v10.i31.11403]
Corresponding Author of This Article
Lian-Peng Zhang, Doctor, MM, Doctor, Department of Respiratory Medicine, Qingzhou Hospital Affiliated to Shandong First Medical University, Qingzhou People's Hospital, No. 1726 Linglongshan Middle Road, Qingzhou 262500, Shandong Province, China. hxzlp2013@126.com
Research Domain of This Article
Respiratory System
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 6, 2022; 10(31): 11403-11410 Published online Nov 6, 2022. doi: 10.12998/wjcc.v10.i31.11403
Relationship between lipids and sleep apnea: Mendelian randomization analysis
Lian-Peng Zhang, Xiao-Xia Zhang
Lian-Peng Zhang, Department of Respiratory Medicine, Qingzhou Hospital Affiliated to Shandong First Medical University, Qingzhou People's Hospital, Qingzhou 262500, Shandong Province, China
Xiao-Xia Zhang, Department of AIDS Voluntary Counseling and Testing, Qingzhou Center for Disease Control and Prevention, Qingzhou 262500, Shandong Province, China
Author contributions: Zhang LP contributed to conceptualization, methodology, software, writing-review, and editing; Zhang XX contributed to formal analysis, writing-review, and editing.
Institutional review board statement: The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). All data base were from public research. No patients were participated in the design or study. Thus, ethical approval was not needed for our study.
Informed consent statement: Since this study does not involve human participation, it is not necessary to sign an informed document.
Conflict-of-interest statement: All authors have no conflicts of interest to declare.
Data sharing statement: The data used in this study are all from published materials, dataset available from https://gwas.mrcieu.ac.uk/.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lian-Peng Zhang, Doctor, MM, Doctor, Department of Respiratory Medicine, Qingzhou Hospital Affiliated to Shandong First Medical University, Qingzhou People's Hospital, No. 1726 Linglongshan Middle Road, Qingzhou 262500, Shandong Province, China. hxzlp2013@126.com
Received: May 8, 2022 Peer-review started: May 8, 2022 First decision: July 12, 2022 Revised: July 26, 2022 Accepted: September 20, 2022 Article in press: September 20, 2022 Published online: November 6, 2022 Processing time: 171 Days and 16.4 Hours
ARTICLE HIGHLIGHTS
Research background
Obstructive sleep apnea (OSA) has a negative effect on serum lipids, but the relationship between serum lipids and OSA is still uncertain.
Research motivation
We explored the direct effect of serum lipids on OSA.
Research objectives
We observed that lipids are not related to OSA, and we need to further look for other markers to predict OSA in the future.
Research methods
First, compared with other observational studies, the genetic variants can be obtained from different sample of individuals, and genetic associations can be obtained from large genome-wide association studies, which can greatly improve the statistical ability to detect small effects of complex phenotypes. Second, the study excluded more confounding factors, excluded heterogeneity and level pleiotropy, and conducted sensitivity tests to make our results more convincing.
Research results
In Mendelian randomization, the inverse variance weighted method manifested that the level of serum lipids including low-density lipoprotein (odds ratio [OR] = 0.99, 95% confidence interval [CI] = 0.99 to 1.00, P = 0.58), high-density lipoprotein (OR = 0.99, 95%CI = 0.99 to 1.00, P = 0.91), triglyceride (OR = 1.00, 95%CI = 0.99 to 1.00, P = 0.92), and total cholesterol (OR = 0.99, 95%CI = 0.99 to 1.00, P = 0.33) was not causally associated with sleep apnea (SA).
Research conclusions
Through MR analysis, this study concludes that serum lipids are not associated with SA.
Research perspectives
We need to find other markers to predict SA in the future.
