Published online Nov 6, 2022. doi: 10.12998/wjcc.v10.i31.11299
Peer-review started: June 23, 2022
First decision: September 5, 2022
Revised: September 14, 2022
Accepted: September 29, 2022
Article in press: September 29, 2022
Published online: November 6, 2022
Processing time: 126 Days and 0.9 Hours
The tumor is a major contributor to endangering human health, traditional Chinese medicine (TCM) monomer is an important source of anti-tumor drugs. Ribonucleotide reductase (RR) is a key enzyme in tumor proliferation, especially its subunit-RRM2. Screening and analysis of TCM monomers with RRM2 inhibition can provide a reference for further anti-tumor drug development.
To screen and analyze potential anti-tumor TCM monomers with a good binding capacity to RRM2, and provide some thoughts for the development of anti-tumor drugs with RRM2 inhibition in the future.
To clarify the relationship between RRM2 and malignant tumors. To clarify the relationship between RRM2 and the prognosis of tumor patients. To screen and analyze potential anti-tumor TCM monomers with a good binding capacity to RRM2, and provide some thoughts for the development of anti-tumor drugs with RRM2 inhibition in the future.
The GEPIA database was used to analyze the level of RRM2 gene expression in normal and tumor tissues as well as RRM2's effect on the overall survival rate of tumor patients. TCM monomers that potentially act on RRM2 were screened via literature mining. Using AutoDock software, the screened monomers were docked with the RRM2 protein.
The expression of RRM2 mRNA in multiple tumor tissues was significantly higher than that in normal tissues, and RRM2 was negatively correlated with the overall survival rate of patients with the majority of tumor types. Berberine, ursolic acid, gambogic acid, cinobufagin, quercetin, daphnetin, and osalmide have inhibitory effects on RRM2. The screened TCM monomers had a strong binding capacity with RRM2 protein.
RRM2 is an important tumor therapeutic target. The screened TCM monomers have a good binding ability with the RRM2.
Their main binding sites could provide new thoughts for the development of anti-tumor drugs with RRM2 inhibition.