Yang F, Pan M, Nie J, Xiao F, Zhang Y. Evaluation of the prognostic nutritional index for the prognosis of Chinese patients with high/extremely high-risk prostate cancer after radical prostatectomy. World J Clin Cases 2022; 10(25): 8863-8871 [PMID: 36157668 DOI: 10.12998/wjcc.v10.i25.8863]
Corresponding Author of This Article
Yuan Zhang, BSc, Chief Physician, Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. tjzy2781@163.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 6, 2022; 10(25): 8863-8871 Published online Sep 6, 2022. doi: 10.12998/wjcc.v10.i25.8863
Evaluation of the prognostic nutritional index for the prognosis of Chinese patients with high/extremely high-risk prostate cancer after radical prostatectomy
Fan Yang, Min Pan, Jin Nie, Fan Xiao, Yuan Zhang
Fan Yang, Min Pan, Jin Nie, Fan Xiao, Yuan Zhang, Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Author contributions: Zhang Y conceptualized and designed this study; Yang F collected the data and drafted the manuscript; Pan M and Nie J analyzed and interpreted the data; Xiao F and Zhang Y were responsible for critically revising the manuscript for important intellectual content; all authors approved the final version for submission.
Institutional review board statement: This study was approved by the Ethics Committee of the Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.
Informed consent statement: The data used in this study were not involved in the patients’ privacy information, so the informed consent was waived by the Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yuan Zhang, BSc, Chief Physician, Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. tjzy2781@163.com
Received: April 19, 2022 Peer-review started: April 19, 2022 First decision: May 11, 2022 Revised: May 22, 2022 Accepted: July 29, 2022 Article in press: July 29, 2022 Published online: September 6, 2022 Processing time: 128 Days and 23.5 Hours
ARTICLE HIGHLIGHTS
Research background
Patients with prostate cancer (PCa) were divided into low-risk, medium-risk, and high-risk groups. The risk level was associated with 10-year disease-free survival after radical prostatectomy. The 10-year disease-free survival rates of the low-risk, medium-risk, and high-risk groups were 83%, 46%, and 29%, respectively.
Research motivation
Predicting the prognosis in advance according to the degree of risk can provide a basis for individualized treatment options and postoperative adjuvant treatment measures for PCa patients, especially for high/extremely high-risk patients.
Research objectives
Prognostic nutritional index (PNI) is considered to have predictive significance in the prognosis of lung cancer, melanoma, and esophageal cancer. PNI is also associated with the prognosis of PCa.
Research methods
Patients with PCa were divided into a high PNI group and low PNI group based on the PNI threshold. The progression-free survival was compared between the two groups. Meanwhile, the influencing factors of biological recurrence were analyzed.
Research results
The progression-free survival of patients in the low PNI group within 5 years was shorter, and the low PNI and positive incisal margin status were independent predictors of biological recurrence in patients with high/extremely high-risk PCa.
Research conclusions
PNI value has predictive significance on the prognosis of patients with high/extremely high-risk PCa.
Research perspectives
Calculating the Youden index was used to determine the optimal critical value of PNI. The progression-free survival of low PNI group and high PNI group were compared by Kaplan-Meier survival analysis. The influencing factors of biological recurrence was analyzed by Cox proportional hazards regression model.
