Liu G, Zhang L, Wang HS, Lin Y, Jin HQ, Wang XD, Qiao WN, Zhang YT, Sun JQ, Liu ZN. Dexmededomidine in pediatric unilateral internal inguinal ring ligation. World J Clin Cases 2022; 10(21): 7376-7385 [PMID: 36157988 DOI: 10.12998/wjcc.v10.i21.7376]
Corresponding Author of This Article
Zhi-Na Liu, BA, Department of Anesthesiology, Baoding Children's Hospital, No. 3399 Hengxiang North Street, Baoding 071000, Hebei Province, China. wenwen9604@163.com
Research Domain of This Article
Anesthesiology
Article-Type of This Article
Randomized Clinical Trial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 26, 2022; 10(21): 7376-7385 Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7376
Dexmededomidine in pediatric unilateral internal inguinal ring ligation
Guang Liu, Ling Zhang, Hui-Se Wang, Yi Lin, Hong-Quan Jin, Xiao-Dan Wang, Wei-Na Qiao, Ya-Tao Zhang, Jiao-Qian Sun, Zhi-Na Liu
Guang Liu, Ling Zhang, Hui-Se Wang, Yi Lin, Hong-Quan Jin, Xiao-Dan Wang, Wei-Na Qiao, Ya-Tao Zhang, Jiao-Qian Sun, Zhi-Na Liu, Department of Anesthesiology, Baoding Children's Hospital, Baoding 071000, Hebei Province, China
Author contributions: Zhang L and Liu ZN have full access to all the data in the study and are responsible for the integrity of the data and the accuracy of the data analysis; Liu G and Liu ZN contributed to conception and design of the study; Wang HS and Lin Y contributed to project supervision; Jin HQ, Wang XD, and Qiao WN drafted the manuscript; all authors contributed to acquisition, analysis, and interpretation of the data, read and critically revised the manuscript, and approved the final manuscript.
Institutional review board statement: This study was conducted in agreement with the GCP standards and Declaration of Helsinki, and approved by the Ethics Committee of the Baoding Children’s Hospital (approval No. 201829).
Clinical trial registration statement: The registration No. ChiCTR2000034105.
Informed consent statement: The parents of all children provided informed consent.
Conflict-of-interest statement: All authors declare no potential conflicting interests related to this paper.
Data sharing statement: The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Na Liu, BA, Department of Anesthesiology, Baoding Children's Hospital, No. 3399 Hengxiang North Street, Baoding 071000, Hebei Province, China. wenwen9604@163.com
Received: November 18, 2021 Peer-review started: November 18, 2021 First decision: December 27, 2021 Revised: February 21, 2022 Accepted: June 4, 2022 Article in press: June 4, 2022 Published online: July 26, 2022 Processing time: 235 Days and 5.1 Hours
ARTICLE HIGHLIGHTS
Research background
Pediatric inguinal hernia is common in children. Safe and effective analgesia strategy remains one of the priorities for pediatric inguinal hernia treatment.
Research motivation
Search for safe and effective analgesia strategy is one of the priorities for inguinal hernia treatment in pediatric practice.
Research objectives
Our aim was to explore the safety and efficacy of dexmededomidine monotherapy for postoperative analgesia in children who received laparoscopic unilateral internal inguinal ring ligation.
Research methods
This randomized single-center controlled trial included children (aged 1-3 years, ASA grade I-II), randomly divided into the D group, DS group, and S group. The analgesia effect, sedative effects, and complications were compared.
Research results
Finally, 377 children were included, of which 125, 126, and 126 were in a dexmededomidine group (D group), a dexmededomidine + sufentanil group (DS group), and a sufentanil group (S group), respectively. The analgesia effect showed no difference among the three groups. The sedative effects were significantly better in the D group than in the S group, but not significantly different from that in the DS group. The incidence of nausea and vomiting was significantly lower in the D group than in the S group and DS group.
Research conclusions
Analgesic effects of dexmededomidine monotherapy were comparable with those of sufentanil alone or in combination with dexmededomidine for children who underwent laparoscopic unilateral internal inguinal ring ligation, with better sedative effects and a lower incidence of adverse events.
Research perspectives
Dexmededomidine for analgesia and sedation is worth to be applied in pediatric inguinal hernia treatment. Pediatric inguinal hernia is common in children.
