Dai M, Wang T, Wang JM, Fang LP, Zhao Y, Thakur A, Wang D. Imaging characteristics of orbital peripheral nerve sheath tumors: Analysis of 34 cases. World J Clin Cases 2022; 10(21): 7356-7364 [PMID: 36158022 DOI: 10.12998/wjcc.v10.i21.7356]
Corresponding Author of This Article
Ting Wang, PhD, Doctor, Department of Respiratory Medicine, Xi'an People's Hospital (The Fourth Xi'an Hospital), No. 21 Jiefang Road, Xincheng District, Xi'an 710004, Shannxi Province, China. hdwt.ok@163.com
Research Domain of This Article
Neuroimaging
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 26, 2022; 10(21): 7356-7364 Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7356
Imaging characteristics of orbital peripheral nerve sheath tumors: Analysis of 34 cases
Min Dai, Ting Wang, Jun-Ming Wang, Li-Ping Fang, Ying Zhao, Asmitananda Thakur, Dong Wang
Min Dai, Department of Rehabilitation Center for Elderly, Beijing Rehabilitation Hospital Affiliated to Capital Medical University, Beijing 100144, China
Ting Wang, Li-Ping Fang, Department of Respiratory Medicine, Xi'an People's Hospital (The Fourth Xi'an Hospital), Xi'an 710004, Shannxi Province, China
Jun-Ming Wang, Dong Wang, Department of Radiology, Xi'an People's Hospital (The Fourth Xi'an Hospital), Xi'an 710004, Shannxi Province, China
Ying Zhao, Department of Pathology, Xi'an People's Hospital (The Fourth Xi'an Hospital), Xi'an 710004, Shannxi Province, China
Author contributions: All authors have read and approved the manuscript; Dai M drafted part of the manuscript, and is responsible for the revision and publication fees; Wang T performed the literature review and drafted part of the manuscript; Wang JM, Fang LP and Zhao Y collected the patient data; Thakur A critically polished the language; Wang D interpreted the data.
Supported bythe Incubation Fund Project of the Xi’an People’s Hospital (The Fourth Xi'an Hospital), No. FZ-75.
Institutional review board statement: Our study was approved by the Institutional Committee for Research Involving Human Subjects of the Xi'an People's Hospital (The Fourth Xi'an Hospital). Informed consent forms listing relevant information needed to be collected were signed and obtained from the participants.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ting Wang, PhD, Doctor, Department of Respiratory Medicine, Xi'an People's Hospital (The Fourth Xi'an Hospital), No. 21 Jiefang Road, Xincheng District, Xi'an 710004, Shannxi Province, China. hdwt.ok@163.com
Received: March 1, 2022 Peer-review started: March 1, 2022 First decision: April 8, 2022 Revised: April 25, 2022 Accepted: June 14, 2022 Article in press: June 14, 2022 Published online: July 26, 2022 Processing time: 132 Days and 5.6 Hours
ARTICLE HIGHLIGHTS
Research background
Peripheral nerve sheath tumors (PNSTs) is a rare group of neoplasms in the orbit. Although computed tomography (CT) and magnetic resonance imaging (MRI) features could provide clues for the diagnosis of PNSTs, there are very few studies detailing the features of these tumors identified using imaging technology at present.
Research motivation
The comprehensive characteristics of 34 patients with PNSTs were collected, and we found that imaging played as an important role in the diagnosis of this rare tumor.
Research objectives
This study was designed to compare the clinical, pathological, CT, and MRI data in 34 patients with periorbital sheath tumors, including 21 schwannomas, 12 neurofibromas, and 1 plexiform neurofibroma.
Research methods
All data were analyzed retrospectively in 34 patients with periorbital sheath tumors diagnosed using histopathology from January 2013 to August 2021.
Research results
Schwannomas mostly occur in the intramuscular space with small tumor volume and rare bone involvement. Neurofibromas develop in the extrapyramidal space with larger tumor volume and more bone involvement. One case of plexiform neurofibroma showed tortuous and diffuse growth along the nerve, with a worm-like appearance on imaging.
Research conclusions
Imaging manifestations have great value in the diagnosis of orbital peripheral nerve sheath tumors.
Research perspectives
Further studies will elucidate the imaging characteristics of all types of orbital PNSTs using larger sample sizes, and focus on the value of imaging in the surgery of orbital PNSTs.
