Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7314
Peer-review started: March 1, 2022
First decision: April 7, 2022
Revised: April 17, 2022
Accepted: June 15, 2022
Article in press: June 15, 2022
Published online: July 26, 2022
Processing time: 131 Days and 22.7 Hours
Prolonged hypoxia can cause acid-base balance disorder, peripheral circulatory failure, blood-pressure reduction, arrhythmia, and other adverse consequences.
Blood-gas parameters, hemodynamic parameters, respiratory mechanical parameters, inflammatory factors, and treatment outcomes were compared between the two groups before and after mechanical-ventilation treatment.
This study aimed to investigate sequential mechanical ventilation’s effect on severe pneumonia complicated by respiratory failure.
Before treatment, patient radial artery blood was collected for post-treatment blood-gas analysis at 24, 48, and 72 h, and oxygen partial pressure, carbon dioxide partial pressure, and pH values were recorded. The Xp-100 blood gas analyzer was used as a detection instrument. Data regarding respiratory mechanics and hemodynamic parameters on the Mindray ECG monitor were recorded. Before treatment, 3 mL of fasting venous blood was extracted from patients 72 h after treatment and placed in an ethylenediaminetetraacetic acid anticoagulant tube; 1 h after centrifuge treatment, serum was collected, and interleukin-6 (IL-6), IL-8, and tumor necrosis factor-α were detected using an enzyme-linked immunosorbent assay kit and detection instrument.
Sequential mechanical ventilation potentially protects alveoli, prevents their atrophy and collapse, reduces the work of respiratory muscles, improves lung compliance, and improves patients’ respiratory failure. Dual-level positive pressure ventilation potentially facilitates the reopening of nonventilatory alveoli, maintains an open airway, and improves the ventilation/blood-flow ratio and hemodynamic parameters. Sequential mechanical ventilation, which potentially improves respiratory system compliance more effectively, corrects the hypoxic state of the body, and facilitates infection control. Sequential mechanical ventilation in the treatment of severe pneumonia complicated by respiratory failure potentially reduces the total mechanical-ventilation time, but does not significantly increase the reintubation rate and mortality of patients, thus conferring a favorable application value to the procedure.
Sequential mechanical ventilation in the treatment of severe pneumonia complicated by respiratory failure is more effective in improving respiratory system compliance, reducing inflammatory response, maintaining hemodynamic stability, and thus improving patient blood-gas level more effectively
To further explore the advantages of sequential mechanical ventilation in the treatment of severe pneumonia complicated with respiratory failure, a large-sample, multi-center study is warranted.