Meta-Analysis
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2022; 10(19): 6483-6495
Published online Jul 6, 2022. doi: 10.12998/wjcc.v10.i19.6483
Diagnostic accuracy of ≥ 16-slice spiral computed tomography for local staging of colon cancer: A systematic review and meta-analysis
Dan Liu, Lin-Mei Sun, Jing-Hua Liang, Lei Song, Xiao-Pei Liu
Dan Liu, Lin-Mei Sun, Lei Song, Xi’an Hospital of Traditional Chinese Medicine, Xi’an 710021, Shaanxi Province, China
Jing-Hua Liang, Shenzhen Traditional Chinese Medicine Anorectal Hospital, Shenzhen 518000, Guangdong Province, China
Xiao-Pei Liu, School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang 710021, Shaanxi Province, China
Author contributions: Liu D wrote the main manuscript and fully participated in all analyses; Liu D and Sun LM contributed to the study concept and design; Liang JH, Liu XP, and Song L participated in literature search, data extraction, and quality assessment; all authors read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lin-Mei Sun, MD, Xi’an Hospital of Traditional Chinese Medicine, No. 69 Fengcheng Eighth Road, Weiyang District, Xi’an 710021, Shaanxi Province, China. 15339183663@163.com
Received: August 19, 2021
Peer-review started: August 19, 2021
First decision: January 10, 2022
Revised: January 24, 2022
Accepted: May 27, 2022
Article in press: May 27, 2022
Published online: July 6, 2022
Processing time: 309 Days and 0.4 Hours
ARTICLE HIGHLIGHTS
Research background

Colorectal cancer is a common, high-mortality cancer. Classified by the World Health Organization as a single entity, colon cancer and rectal cancer are largely different in their diagnoses, treatments, surgical methods, and recurrence rates. Since early symptoms are easily overlooked, it is important to find a more accurate staging method.

Research motivation

By looking for a method to detect local stages of colon cancer, we hoped to find a method that has better accuracy and can distinguish between high-risk and low-risk colon cancer.

Research objectives

This study aimed to evaluate the diagnostic accuracy of ≥ 16-slice spiral computed tomography (SCT) in detecting local colon cancer staging.

Research methods

Based on the PubMed, EMBASE, Cochrane Library, and Web of Science databases, computers were used to search the literature from the establishment of the database to April 2021. The results of the diagnostic tests on ≥ 16-slice SCT for local colon cancer staging were collected according to the inclusion criteria, and then the data were extracted and assessed on the basis of the Quality Assessment Checklist of the Institute of Economics of Canada. Afterward, a meta-analysis was performed using the statistical software Meta-disc 14.0 and Stata 15.0.

Research results

Eleven studies with a total of 1613 subjects were included. The pooled sensitivity, pooled specificity, pooled negative LR, pooled diagnostic odds ratio, and the area under the fitted receiver operating characteristic curve of ≥ 16-slice SCT for colon cancer T staging and N staging were analyzed. The results revealed that the sensitivity and specificity of ≥ 16-slice SCT for colon cancer T staging were acceptable, while the sensitivity of colon cancer N staging was relatively low, but its specificity was acceptable.

Research conclusions

It was revealed in this study that the sensitivity and specificity of ≥ 16-slice SCT for colon cancer T staging are acceptable, while there is a relatively low sensitivity and specificity for colon cancer N staging, which is indicative of the good diagnostic value of ≥ 16-slice SCT for local staging of colon cancer. These findings need to be confirmed in further clinical studies.

Research perspectives

In the future, further clinical studies should be carried out to prove the accuracy of 16-slice SCT for local staging of colon cancer.