Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 7, 2022; 10(1): 136-142
Published online Jan 7, 2022. doi: 10.12998/wjcc.v10.i1.136
Age, alcohol, sex, and metabolic factors as risk factors for colonic diverticulosis
Ye Yan, Jian-Sheng Wu, Shuang Pan
Ye Yan, Jian-Sheng Wu, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Author contributions: Yan Y designed and performed the research and wrote the paper; Wu JS collected data and designed the research; Pan S provided clinical advice and supervised the report.
Institutional review board statement: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee of the First Affiliated Hospital of Wenzhou Medical University and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent statement: The requirement for informed consent was waived due to the retrospective nature of the study and the anonymity of the data.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The data are available upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shuang Pan, MD, Doctor, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, No. 2 Nanbaixiang Street, Wenzhou 325000, Zhejiang Province, China. panshuang@wzhospital.cn
Received: July 4, 2021
Peer-review started: July 4, 2021
First decision: October 18, 2021
Revised: October 28, 2021
Accepted: November 28, 2021
Article in press: November 28, 2021
Published online: January 7, 2022
Processing time: 179 Days and 1.1 Hours
ARTICLE HIGHLIGHTS
Research background

The pathogenesis of colonic diverticulosis is not well understood.

Research motivation

Only a few studies on colonic diverticulosis have been reported in mainland China. Understanding the true prevalence of colonic diverticulosis and the risk factors associated with it will aid in the prevention and treatment of this disease.

Research objectives

To evaluate the prevalence of and risk factors for asymptomatic colorectal diverticulosis in mainland China.

Research methods

From August 2016 to July 2020, 6180 asymptomatic individuals were enrolled in this cross-sectional study.

Research results

Logistic regression analysis revealed that an age ≥ 60 years (adjusted odds ratio [OR] 2.149, 95% confidence interval [CI] 1.511-3.057, P < 0.001), male sex (adjusted OR: 1.878, 95%CI: 1.373-2.568, P < 0.001), obesity (adjusted OR: 1.446, 95%CI: 1.100-1.902, P = 0.008), alcohol intake (adjusted OR: 1.518, 95%CI: 1.213-1.901, P < 0.001), hypertension (adjusted OR: 1.454, 95%CI: 1.181-1.789, P < 0.001), hypertriglyceridemia (adjusted OR: 1.287, 95%CI: 1.032-1.607, P = 0.025), and hyperuricemia (adjusted OR: 1.570, 95%CI: 1.257-1.961, P < 0.001) significantly increased the risk of colonic diverticulosis.

Research conclusions

Advanced age, male sex, alcohol intake, obesity, and other metabolic-related factors, such as hypertension, hypertriglyceridemia, and hyperuricemia, were independent risk factors for colonic diverticulosis.

Research perspectives

Our findings are of educative value and are likely to aid clinicians in the management of patients with this disease entity.