Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2021; 9(7): 1748-1754
Published online Mar 6, 2021. doi: 10.12998/wjcc.v9.i7.1748
Congenital fiber-type disproportion presenting with type II respiratory failure after delivery: A case report
Hong-Mei Yang, Jian-Xing Guo, Yi-Min Yang
Hong-Mei Yang, Jian-Xing Guo, Yi-Min Yang, Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Yang YM and Yang HM conceptualized the case report and drafted the methodology; Yang HM and Guo JX were responsible for data curation and performed the formal analyses; Yang HM performed the investigation and drafted the original manuscript; Yang YM was responsible for reviewing and editing the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Yi-Min Yang, MD, PhD, Doctor, Department of Intensive Care Unit, The First Hospital of Jilin University, No. 1 Xinmin Dajie, Changchun 130021, Jilin Province, China.
Received: December 2, 2020
Peer-review started: December 2, 2020
First decision: December 21, 2020
Revised: December 26, 2020
Accepted: January 21, 2021
Article in press: January 21, 2021
Published online: March 6, 2021

Congenital fiber-type disproportion (CFTD) is a form of congenital myopathy. CFTD is rare, especially when presenting in patients with critical illnesses. Here, we report a case of CFTD presenting with type II respiratory failure after delivery and provide a review of the literature on CFTD.


A 30-year-old woman was admitted to the obstetrics department of our hospital with premature rupture of the fetal membrane and with 7 h of regular contractions. After delivery, the patient experienced a refractory type II respiratory failure. Physical examination along with diagnostic procedures such as electromyography and biopsy confirmed CFTD. Use of invasive ventilator followed by intermittent use of noninvasive ventilator attenuated her symptoms. The patient recovered after ventilator-assisted respiration and was weaned off the noninvasive ventilator on the seventh day postpartum.


Congenital myopathy should be considered a differential diagnosis for type II respiratory failures that cannot be attributed to other diseases.

Keywords: Congenital fiber-type disproportion, Congenital myopathy, Type II respiratory failure, Delivery, Systematic review, Case report

Core Tip: The etiology of type II respiratory failure is complex. Congenital fiber-type disproportion is one of the rare causes, whose course is static or slowly progressive. Here, we present a rare case of congenital fiber-type disproportion in a 30-year-old woman, whose first symptom was refractory type II respiratory failure postpartum. This case reflects the importance of considering the possibility of congenital myopathy when looking for the cause of type II respiratory failure.