Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 26, 2021; 9(6): 1367-1378
Published online Feb 26, 2021. doi: 10.12998/wjcc.v9.i6.1367
Periodontally accelerated osteogenic orthodontics with platelet-rich fibrin in an adult patient with periodontal disease: A case report and review of literature
Min Xu, Xiao-Yu Sun, Jian-Guang Xu
Min Xu, Xiao-Yu Sun, Stomatological Hospital and College, Anhui Medical University, Hefei 230032, Anhui Province, China
Jian-Guang Xu, Department of Orthodontics, Anhui Medical University, Hefei 230032, Anhui Province, China
Author contributions: Xu M analyzed and interpreted the imaging findings; Sun XY reviewed the literature and drafted the manuscript; Xu JG was the patient’s dentist and was responsible for the revision of the manuscript; All authors issued final approval for the version to be submitted.
Supported by Natured Science Foundation of Anhui Province, No. 1908085MH255.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Jian-Guang Xu, MD, PhD, Associate Professor, Doctor, Department of Orthodontics, Anhui Medical University, No. 69, Meishan Road, Hefei 230032, Anhui Province, China.
Received: September 22, 2020
Peer-review started: September 22, 2020
First decision: December 3, 2020
Revised: December 15, 2020
Accepted: December 26, 2020
Article in press: December 26, 2020
Published online: February 26, 2021

In the clinical scenario, adult patients with periodontal diseases and dental malformation, characterized by dental crowding in lower anterior teeth with the thin biotype, often require orthodontic treatment. This case report aimed to evaluate the clinical and radiographic outcomes of periodontally accelerated osteogenic orthodontics (PAOO) combined with autologous platelet-rich fibrin (PRF) in an adult patient with class I malocclusion along with dental crowding, a thin periodontal biotype, and buccal plate deficiency.


A 32-year-old female complaining of dental crowding and gingival bleeding was referred to the orthodontic clinic. The patient underwent periodontal risk assessment prior to orthodontic treatment. She was diagnosed with a high risk of gingival recession due to dental crowding, root prominence, loss of buccal plates, and a thin gingival tissue biotype. The treatment regimen included PAOO combined with autologous PRF for alveolar augmentation and interproximal enamel reduction for moderate dental crowding. Clinically, PAOO-assisted orthodontic tooth movement in this case showed enhanced periodontium remodeling. Radiographic outcomes also showed statistically significant improvements (P < 0.01) in the mandibular buccal alveolar bone.


This case report suggests the combination of autologous PRF with PAOO to enhance bone augmentation and long-term tissue support in adult orthodontic patients with periodontal disease.

Keywords: Periodontally accelerated osteogenic orthodontics, Orthodontic tooth movement, Platelet-rich fibrin, Bone augmentation, Periodontal biotype, Case report

Core Tip: Periodontally accelerated osteogenic orthodontics (PAOO) has been widely used in the treatment of patients with periodontal diseases and dental malformation. However, the combined therapy with autologous platelet-rich fibrin and PAOO in orthodontic practice has been rarely reported. The aim of this case report was to evaluate clinical and radiographic outcomes of PAOO combined with autologous platelet-rich fibrin in an adult patient with class I malocclusion with thin periodontal biotype and buccal plate deficiency in order to provide guidance for future clinical diagnosis and treatment.