Yu XQ, Deng HB, Liu Y, Qu C, Duan ZH, Tong ZH, Liu YX, Li WQ. Serum magnesium level as a predictor of acute kidney injury in patients with acute pancreatitis. World J Clin Cases 2021; 9(35): 10899-10908 [PMID: 35047600 DOI: 10.12998/wjcc.v9.i35.10899]
Corresponding Author of This Article
Wei-Qin Li, MD, Professor, Medical School, Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing 210009, Jiangsu Province, China. liweiqindr@nju.edu.cn
Research Domain of This Article
Critical Care Medicine
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 16, 2021; 9(35): 10899-10908 Published online Dec 16, 2021. doi: 10.12998/wjcc.v9.i35.10899
Serum magnesium level as a predictor of acute kidney injury in patients with acute pancreatitis
Xian-Qiang Yu, Hong-Bin Deng, Yang Liu, Cheng Qu, Ze-Hua Duan, Zhi-Hui Tong, Yu-Xiu Liu, Wei-Qin Li
Xian-Qiang Yu, Wei-Qin Li, Medical School, Southeast University, Nanjing 210009, Jiangsu Province, China
Hong-Bin Deng, Department of Critical Care Medicine, Nanjing Medical University, Nanjing 210002, Jiangsu Province, China
Yang Liu, Cheng Qu, Ze-Hua Duan, Department of Critical Care Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China
Zhi-Hui Tong, Yu-Xiu Liu, Wei-Qin Li, Department of Critical Care Medicine, General Hospital of Eastern Theater Command, Nanjing 210002, Jiangsu Province, China
Author contributions: Yu XQ and Deng HB made equal contributions to the article; Yu XQ and Deng HB completed the design and writing of the paper; Liu Y, Qu C, Duan ZH and Tong ZH participated in the revision and design of the article; Liu YX and Li WQ participated in the overall design and revision of the paper.
Supported byNational Natural Science Foundation of China, No. 82070669.
Institutional review board statement: The study was reviewed and approved by the Nanjing Jinling Hospital Institutional Review Board.
Informed consent statement: All authors have agreed to publish this article.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: The datasets used or analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Received: June 30, 2021 Peer-review started: June 30, 2021 First decision: August 19, 2021 Revised: September 1, 2021 Accepted: October 31, 2021 Article in press: October 31, 2021 Published online: December 16, 2021 Processing time: 163 Days and 2.8 Hours
Abstract
BACKGROUND
Decreased serum magnesium (Mg2+) is commonly seen in critically ill patients. Hypomagnesemia is significantly more frequent in patients with severe acute pancreatitis. Acute kidney injury (AKI) in patients with acute pancreatitis (AP) is associated with an extremely high mortality. The association underlying serum Mg2+ and AKI in AP has not been elucidated.
AIM
To explore the association between serum Mg2+ on admission and AKI in patients with AP.
METHODS
A retrospective observational study was conducted in a cohort of patients (n = 233) with AP without any renal injury before admission to our center from August 2015 to February 2019. Demographic characteristics on admission, severity score, laboratory values and in-hospital mortality were compared between patients with and without AKI.
RESULTS
A total of 233 patients were included for analysis, including 85 with AKI. Compared to patients without AKI, serum Mg2+ level was significantly lower in patients with AKI at admission [OR = 6.070, 95%CI: 3.374-10.921, P < 0.001]. Multivariate logistic analysis showed that lower serum Mg2+ was an independent risk factor for AKI [OR = 8.47, 95%CI: 3.02-23.72, P < 0.001].
CONCLUSION
Our analysis indicates that serum Mg2+ level at admission is independently associated with the development of AKI in patients with AP and may be a potential prognostic factor.
Core Tip: Acute kidney injury (AKI) is a serious complication of acute pancreatitis (AP) and is often difficult to predict at an early stage. However, our clinical analysis found that serum Mg2+ on admission is a good predictor of the occurrence of AKI in AP patients. Therefore, this may provide a new method for the early prediction of AKI after AP.
