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Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 16, 2021; 9(35): 10746-10764
Published online Dec 16, 2021. doi: 10.12998/wjcc.v9.i35.10746
Management of acute kidney injury in gastrointestinal tumor: An overview
Yi-Qi Su, Yi-Yi Yu, Bo Shen, Feng Yang, Yu-Xin Nie
Yi-Qi Su, Department of Nephrology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen 361015, Fujian Province, China
Yi-Yi Yu, Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Bo Shen, Yu-Xin Nie, Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Feng Yang, Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China
Author contributions: Su YQ and Shen B designed, reviewed the manuscript; Su YQ wrote the manuscript; Yu YY, Yang F and Nie YX proofread the manuscript; all authors have read and approved the final manuscript.
Supported by Shanghai ShenKang Hospital Development Center, No. SHDC12018127.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Xin Nie, MD, Attending Doctor, Department of Nephrology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China. nie.yuxin@zs-hospital.sh.cn
Received: March 3, 2021
Peer-review started: March 3, 2021
First decision: June 23, 2021
Revised: July 8, 2021
Accepted: September 6, 2021
Article in press: September 6, 2021
Published online: December 16, 2021
Processing time: 281 Days and 23.9 Hours
Abstract

Gastrointestinal tumors remain a global health problem. Acute kidney injury (AKI) is a common complication during the treatment of gastrointestinal tumors. AKI can cause a decrease in the remission rate and an increase in mortality. In this review, we analyzed the causes and risk factors for AKI in gastrointestinal tumor patients. The possible mechanisms of AKI were divided into three groups: pretreatment, intrafraction and post-treatment causes. Treatment and prevention measures were proposed according to various factors to provide guidance to clinicians and oncologists that can reduce the incidence of AKI and improve the quality of life and survival rate of gastrointestinal tumor patients.

Keywords: Gastrointestinal tumor, Acute kidney injury, Risk factors, Treatment, Preventive measures, Enhanced recovery pathways

Core tip: This review analyzed the causes and risk factors for acute kidney injury (AKI) in gastrointestinal tumor patients, and possible mechanism of AKI were divided into three groups: pretreatment, intrafraction and post-treatment causes. In response to these possible causes of AKI, treatment and preventive measures have been proposed based on the latest developments. This article intends to provide guidance of AKI during the treatment of gastrointestinal tumor patients to clinicians and oncologists.