Liu W, Du JJ, Li ZH, Zhang XY, Zuo HD. Liver injury associated with acute pancreatitis: The current status of clinical evaluation and involved mechanisms. World J Clin Cases 2021; 9(34): 10418-10429 [PMID: 35004974 DOI: 10.12998/wjcc.v9.i34.10418]
Corresponding Author of This Article
Hou-Dong Zuo, MD, Doctor, Teacher, Sichuan Key Laboratory of Medical Imaging, Department of Radiology, The Affiliated Hospital of North Sichuan Medical College, No. 63 Wenhua Road, Shunqing District, Nanchong 637000, Sichuan Province, China.zuohoud@163.com
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 6, 2021; 9(34): 10418-10429 Published online Dec 6, 2021. doi: 10.12998/wjcc.v9.i34.10418
Liver injury associated with acute pancreatitis: The current status of clinical evaluation and involved mechanisms
Wei Liu, Juan-Juan Du, Zeng-Hui Li, Xin-Yu Zhang, Hou-Dong Zuo
Wei Liu, Juan-Juan Du, Zeng-Hui Li, Xin-Yu Zhang, Hou-Dong Zuo, Sichuan Key Laboratory of Medical Imaging, Department of Radiology, The Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Author contributions: Liu W wrote the paper; Du JJ, Li ZH, and Zhang XY reviewed the literature; Zuo HD designed the outline and coordinated the writing of the paper.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hou-Dong Zuo, MD, Doctor, Teacher, Sichuan Key Laboratory of Medical Imaging, Department of Radiology, The Affiliated Hospital of North Sichuan Medical College, No. 63 Wenhua Road, Shunqing District, Nanchong 637000, Sichuan Province, China.zuohoud@163.com
Received: March 18, 2021 Peer-review started: March 18, 2021 First decision: July 3, 2021 Revised: July 16, 2021 Accepted: September 14, 2021 Article in press: September 14, 2021 Published online: December 6, 2021
Abstract
Acute pancreatitis (AP) is a very common acute disease, and the mortality rate of severe AP (SAP) is between 15% and 35%. The main causes of death are multiple organ dysfunction syndrome and infections. The mortality rate of patients with SAP related to liver failure is as high as 83%, and approximately 5% of the SAP patients have fulminant liver failure. Liver function is closely related to the progression and prognosis of AP. In this review, we aim to elaborate on the clinical manifestations and mechanism of liver injury in patients with AP.
Core Tip: Several studies have contributed to the pathophysiology and clinical trials of liver dysfunction associated with acute pancreatitis (AP). However, great progress has been made on liver injury-associated AP (LIAAP) based on the published literature. This review aims to summarize the research progress of LIAAP's clinical manifestations and underlying mechanisms, which can provide new insights for further understanding and better treatment of AP and LIAAP.
