Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2021; 9(31): 9680-9685
Published online Nov 6, 2021. doi: 10.12998/wjcc.v9.i31.9680
Metachronous squamous cell carcinoma of pancreas and stomach in an elderly female patient: A case report
Ji Hyun Kim, Chang Don Kang, Kyungyul Lee, Kyu-Hyoung Lim
Ji Hyun Kim, Chang Don Kang, Kyu-Hyoung Lim, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon 24341, Kangwon Do, South Korea
Kyungyul Lee, Department of Pathology, Kangwon National University School of Medicine, Chuncheon 24341, Kangwon Do, South Korea
Author contributions: Kang CD was the patient’s doctor; Kim JH performed endoscopy; Kim JH and Lim KH contributed to reviewing of literature and drafting of manuscript; Lee K performed histological analysis; Lim KH supervised this study and revised the manuscript.
Informed consent statement: We could not receive written informed consent for publication as the patient had already passed away.
Conflict-of-interest statement: The authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kyu-Hyoung Lim, MD, PhD, Associate Professor, Department of Internal Medicine, Kangwon National University School of Medicine, 156 Baengnyeong-ro, Chuncheon 24341, Kangwon Do, South Korea. kyuhyoung.lim@kangwon.ac.kr
Received: July 13, 2021
Peer-review started: July 13, 2021
First decision: August 19, 2021
Revised: August 25, 2021
Accepted: September 10, 2021
Article in press: September 10, 2021
Published online: November 6, 2021
Processing time: 108 Days and 1.1 Hours
Abstract
BACKGROUND

Squamous cell carcinoma (SCC) in pancreas and stomach is a rare histologic subtype with aggressive behavior, poor prognosis, and no standardized therapy. Pancreatic SCC or gastric SCC has been previously reported. However, case of SCC occurring in both the pancreas and the stomach has not been reported yet.

CASE SUMMARY

A 75-year-old female with prior history of hypertension and diabetes mellitus visited our hospital with complaint of abdominal pain that started three months ago. Computed tomography (CT) scan of the abdomen showed 3.3 cm mass at the distal pancreas. She received surgical resection which was histologically found to be SCC of the pancreas with clear resection margins. After she was discharged, she no longer visited the hospital. Three years later, she was referred to our hospital after showing abnormal findings on a gastroscopy performed at another hospital. Gastroscopy revealed a single, 2cm sized, ill-defined irregular flat and hyperemic mass at high body. Histologic finding of the mass was SCC. CT scan and positive emission tomography CT showed metastatic lesions to the liver and the peritoneum. She received combination chemotherapy with capecitabine and oxaliplatin. However, she passed away 6 mo after diagnosis of gastric SCC.

CONCLUSION

To the best of our knowledge, this is the first case of metachronous SCC of stomach occurring after diagnosis of pancreatic SCC.

Keywords: Squamous cell carcinoma; Pancreas; Stomach; Metachronous; Pancreatectomy; Case report

Core Tip: Pancreatic squamous cell carcinoma (SCC) and gastric SCC are very rare malignancies with aggressive behavior, poor prognosis, and no standardized therapy. To the best of our knowledge, this is the first case report of metachronous gastric SCC occurring at three years after curative resection of pancreatic cancer.