Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2021; 9(28): 8509-8517
Published online Oct 6, 2021. doi: 10.12998/wjcc.v9.i28.8509
Synchronous concomitant pancreatic acinar cell carcin and gastric adenocarcinoma: A case report and review of literature
Tian Fang, Ting-Ting Liang, Yi-Zhuo Wang, Hai-Tao Wu, Shu-Han Liu, Chang Wang
Tian Fang, Ting-Ting Liang, Yi-Zhuo Wang, Hai-Tao Wu, Shu-Han Liu, Chang Wang, Department of Oncology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Fang T and Liang TT contributed equally to this work; Fang T carried out conceptualization, data sorting and manuscript writing; Liang TT carried out investigation and supervision; Wang YZ was responsible for visualization; Wu HT, Liu SH and Wang C were responsible for review and editing writing; all authors have read and approved the manuscript.
Informed consent statement: Informed consent was obtained from the patient.
Conflict-of-interest statement: All the authors are aware of the content of the manuscript and have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chang Wang, MD, Chief Doctor, Department of Oncology, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130021, Jilin Province, China. wangchang@jlu.edu.cn
Received: April 5, 2021
Peer-review started: April 5, 2021
First decision: July 5, 2021
Revised: July 19, 2021
Accepted: August 25, 2021
Article in press: August 25, 2021
Published online: October 6, 2021
Processing time: 175 Days and 22.9 Hours
Abstract
BACKGROUND

Multiple primary malignant tumors are two or more malignancies in an individual without any relationship between the neoplasms. In recent years, an increasing number of cases have been reported. However, concomitant primary gastric and pancreatic cancer reported a relatively small incidence, involving no pancreatic acinar cell carcinoma reports. Here, we present the first case of concomitant pancreatic acinar cell carcinoma and gastric adenocarcinoma.

CASE SUMMARY

A 69-year-old male presented to our department with a history of vomiting, epigastric pain, and weight loss. Imaging revealed space-occupying lesions in the stomach and the tail of the pancreas, respectively. The patient underwent laparoscopic radical gastrectomy and pancreatectomy simultaneously. The pathologies of surgical specimens were completely different: The resected gastric specimen was moderate to poorly differentiated adenocarcinoma, whereas the pancreatic tumor was consistent with acinar cell carcinoma. The patient was treated with six cycles of oxaliplatin and S-1 chemotherapy. As of March 2021, the patient was healthy without any recurrence or metastasis. After thoroughly reviewing the literature on simultaneous pancreatic and gastric cancers at home and abroad, we discussed the clinical characteristics of these rare synchronous double cancers. Most of the cases had undergone surgery and adjuvant chemotherapy, and all of the cases were pathologically confirmed by the postoperative specimen.

CONCLUSION

Synchronous pancreatic acinar cells and gastric adenocarcinoma can occur and should be considered when tumors are found in these organs.

Keywords: Synchronous concomitant cancers; Pancreatic neoplasms; Stomach neoplasms; Pancreatic acinar cell carcinoma; Surgical procedures; Case report

Core Tip: Acinar cell carcinoma of the pancreas is a rare form of pancreatic cancer, and the incidence of synchronous concomitant pancreatic and gastric cancer is relatively low. We report a patient with simultaneous acinar cell carcinoma of the pancreas with gastric cancer, and he underwent radical surgery for both the pancreas and the stomach. This is the first case of concomitant cancers related to pancreatic acinar cell carcinoma and gastric cancer. We also reviewed the literature on simultaneous pancreatic and gastric cancers.