Shi Y, Lin PY, Ruan YM, Lin CF, Hua SS, Li B. Quantitative analysis of early diabetic retinopathy based on optical coherence tomography angiography biological image. World J Clin Cases 2021; 9(25): 7365-7371 [PMID: 34616803 DOI: 10.12998/wjcc.v9.i25.7365]
Corresponding Author of This Article
Bo Li, MD, Attending Doctor, Department of Ophthalmology, Ningbo First Hospital, No. 59 Liuting Street, Haishu District, Ningbo 315000, Zhejiang Province, China. nblibo@foxmail.com
Research Domain of This Article
Ophthalmology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 6, 2021; 9(25): 7365-7371 Published online Sep 6, 2021. doi: 10.12998/wjcc.v9.i25.7365
Quantitative analysis of early diabetic retinopathy based on optical coherence tomography angiography biological image
Yan Shi, Peng-Yao Lin, Yi-Meng Ruan, Cheng-Fei Lin, Shan-Shan Hua, Bo Li
Yan Shi, Peng-Yao Lin, Yi-Meng Ruan, Cheng-Fei Lin, Shan-Shan Hua, Bo Li, Department of Ophthalmology, Ningbo First Hospital, Ningbo 315000, Zhejiang Province, China
Author contributions: Shi Y and Lin PY design the study; Ruan YM and Lin CF drafted the work and collected the data; Hua SS and Li B analysed and interpreted data and wrote the article.
Supported byNingbo Natural Science Foundation of China, No. 2018A610362.
Institutional review board statement: The study was reviewed and approved by the Ningbo No. 1 Hospital Institutional Review Board (Approval No. 2018-R072).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None of the authors has a financial interest in any of the products, devices, or drugs mentioned in this manuscript.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bo Li, MD, Attending Doctor, Department of Ophthalmology, Ningbo First Hospital, No. 59 Liuting Street, Haishu District, Ningbo 315000, Zhejiang Province, China. nblibo@foxmail.com
Received: April 8, 2021 Peer-review started: April 8, 2021 First decision: April 28, 2021 Revised: July 3, 2021 Accepted: July 28, 2021 Article in press: July 28, 2021 Published online: September 6, 2021
Abstract
BACKGROUND
With the development of the economy and improvements in living standards, the incidences of diabetes mellitus (DM) and diabetic retinopathy (DR), which is a complication of DM, are on the rise.
AIM
To analyze early DR in patients with macular zone changes in biological images using optical coherence tomography angiography
METHODS
A prospective case study was performed on 59 participants: 35 healthy eyes (control group), 35 eyes with diabetes but no DR group (no DR group), and 35 eyes with mild DR (NPDR group). All quantitative comparisons of parameters, including the fovea vascularity area, circularity index, and vascular complexity parameters, were performed using a biological image analysis software.
RESULTS
The foveal avascular zone (FAZ) area, FAZ circularity index, number of branches in the area, and the total of the single branches’ length in the area was 0.366 ± 0.031, 0.834 ± 0.037, 3241.8 ± 268.3, and 3.860 × 107 ± 0.194 × 107, and 0.421 ± 0.030, 0.739 ± 0.023, 2956.6 ± 476.4, and 3.177 × 107 ± 0.161 × 107 in the no DR group and the NPDR group, respectively, which were significantly different from the corresponding parameters of the control group (P < 0.05). Moreover, there were significant differences between these two groups (P < 0.05).
CONCLUSION
This study shows that early microcirculation changes in the macular area of the retina is associated with disease progression. Early changes in DR can be analyzed using optical coherence tomography angiography.
Core Tip: Optical coherence tomography angiography has the advantage of being rapid, noninvasive, high-resolution, repeatable, and consistent. It can also be used as an early fundus screening method for patients with diabetes mellitus.
