Lourdusamy D, Mupparaju VK, Sharif NF, Ibebuogu UN. Aortic stenosis and Heyde’s syndrome: A comprehensive review. World J Clin Cases 2021; 9(25): 7319-7329 [PMID: 34616798 DOI: 10.12998/wjcc.v9.i25.7319]
Corresponding Author of This Article
Dennisdhilak Lourdusamy, MD, Attending Doctor, Internal Medicine, Methodist South Hospital, 1300 Wesley Dr, Memphis, TN 38116, United States. drdennisdhilak@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dennisdhilak Lourdusamy, Vamsee Krishna Mupparaju, Internal Medicine, Methodist South Hospital, Memphis, TN 38116, United States
Navila Fahmida Sharif, Internal Medicine, University of Tennessee Health Science Center, Memphis, TN 38103, United States
Uzoma N Ibebuogu, Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, TN 38163, United States
Author contributions: Lourdusamy D contributed to the initial draft and final revision of the manuscript; Mupparaju VK contributed to the editing, literature review and tables and figures; Sharif NF contributed to literature review and referencing; Ibebuogu UN contributed to final revision and critical analysis; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dennisdhilak Lourdusamy, MD, Attending Doctor, Internal Medicine, Methodist South Hospital, 1300 Wesley Dr, Memphis, TN 38116, United States. drdennisdhilak@gmail.com
Received: May 25, 2021 Peer-review started: May 25, 2021 First decision: June 21, 2021 Revised: July 7, 2021 Accepted: July 26, 2021 Article in press: July 26, 2021 Published online: September 6, 2021 Processing time: 97 Days and 17.8 Hours
Abstract
Heyde’s syndrome is an under reported systemic disease of gastrointestinal and cardiac manifestation in older adults. It is characterized by a triad of aortic stenosis, angiodysplasia with bleeding and acquired von Willebrand syndrome. It is characterized by proteolysis of high molecular weight multimers of von Willebrand Factor and loss of platelet mediated homeostasis. Heyde’s syndrome is a treatable condition in most cases, especially in the current era of evolution in interventional cardiology and gastroenterology. There are currently no established guidelines in the management of this condition due to paucity of high quality studies, which warrant future trials. High index of suspicion and increasing the awareness of the syndrome among the general practitioners and sub-specialists will improve the diagnostic potential of Heyde’s syndrome. Future studies may change the management aspect of Heyde's syndrome and pave a path for drawing specific guidelines and algorithms. The aim of our review article is to summarize the basic pathophysiology, diagnostics and management of Heyde’s syndrome with a special attention to Transcatheter aortic valve replacement.
Core Tip: We summarize the literature on the aortic valve replacement in aortic stenosis and angiodysplasia (Heyde's syndrome). This is a very attractive area of interest for interventional gastroenterologists and cardiologists. Future studies may change the management aspect of Heyde's syndrome and pave a path for drawing specific guidelines and algorithms.
