Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2021; 9(24): 7251-7260
Published online Aug 26, 2021. doi: 10.12998/wjcc.v9.i24.7251
Coexistent vestibular schwannoma and meningioma in a patient without neurofibromatosis: A case report and review of literature
Li-Yan Zhao, Yi-Ning Jiang, Yu-Bo Wang, Yang Bai, Ying Sun, Yun-Qian Li
Li-Yan Zhao, Ying Sun, Department of Clinical Laboratory, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
Yi-Ning Jiang, Yu-Bo Wang, Yang Bai, Yun-Qian Li, Department of Neurosurgery, First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Zhao LY and Jiang YN designed the study; collected analyzed, and interpreted data, wrote the manuscript and reviewed the literature; Li YQ and Wang YB performed the surgery, collected, analyzed, and interpreted data; Sun Y and Bai Y corrected the English, made critical revisions, and approved the final version; Li YQ collected, analyzed, or interpreted data, made critical revision of important intellectual content, approved publication of the final version, and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved; All authors agreed to be accountable for the content of the work.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun-Qian Li, MD, PhD, Chief Doctor, Neurosurgeon, Professor, Department of Neurosurgery, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130021, Jilin Province, China. yunqian@jlu.edu.cn
Received: April 25, 2021
Peer-review started: April 25, 2021
First decision: May 24, 2021
Revised: June 2, 2021
Accepted: June 15, 2021
Article in press: June 15, 2021
Published online: August 26, 2021
Abstract
BACKGROUND

The simultaneous occurrence of schwannoma and meningioma in the absence of neurofibromatosis (NF) or a previous history of irradiation is exceedingly rare, as only 10 intracranial cases have been reported to date. Herein, we report a case of a coexistent cavernous sinus meningioma and ipsilateral vestibular schwannoma (VS) in a female patient without NF or a history of exposure to irradiation.

CASE SUMMARY

A 63-year-old woman presented with progressive left-side hearing loss and tinnitus over the previous year. In the past 6 mo, she developed facial numbness and intermittent headaches. Magnetic resonance imaging showed two lesions that were located on the left side of the cerebellopontine angle and parasellar region. Both lesions were totally resected via the left retrosigmoid approach. Histopathological examination revealed a VS and a meningioma. The patient did not have a family history or clinical or radiological signs of NF.

CONCLUSION

The coincident occurrence of VS and meningioma within close vicinity is very rare, and the pathogenesis is unclear. A careful whole-body examination needs to be conducted to exclude NF. Surgical treatment with the goal of total tumor resection is the best therapy. Additional studies are needed for a better understanding of the mechanisms that lead to the development of tumor growth in multiple locations.

Keywords: Concurrent, Diagnosis, Meningioma, Neurofibromatosis, Schwannoma, Case report

Core Tip: Coexistent schwannoma and meningioma in the absence of neurofibromatosis or a history of irradiation are extremely rare. To the best of our knowledge, only 10 intracranial cases have been reported to date. Herein, we present the case of a coexistent cavernous sinus meningioma and ipsilateral vestibular schwannoma (VS) in a 63-year-old woman. This is the first report of a concurrent meningioma outside of the cerebellopontine angle, along with a coexisting VS. The medical literature was reviewed and the typical histopathological and radiological features of this rare tumor are described, with a detailed discussion of the diagnosis, treatment, and prognosis.