Lu ZH, Yu WL, Sun Y. Multiple immune function impairments in diabetic patients and their effects on COVID-19. World J Clin Cases 2021; 9(24): 6969-6978 [PMID: 34540952 DOI: 10.12998/wjcc.v9.i24.6969]
Corresponding Author of This Article
Yun Sun, MD, Associate Professor, Chief Doctor, Teacher, Department of Critical Care Medicine, The Second Affiliated Hospital, Anhui Medical University, No. 678 Furong Road, Hefei 230601, Anhui Province, China. sunyun15@163.com
Research Domain of This Article
Emergency Medicine
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 26, 2021; 9(24): 6969-6978 Published online Aug 26, 2021. doi: 10.12998/wjcc.v9.i24.6969
Multiple immune function impairments in diabetic patients and their effects on COVID-19
Zhong-Hua Lu, Wei-Li Yu, Yun Sun
Zhong-Hua Lu, Wei-Li Yu, Yun Sun, Department of Critical Care Medicine, The Second Affiliated Hospital, Anhui Medical University, Hefei 230601, Anhui Province, China
Author contributions: Lu ZH and Sun Y participated in the conception and drafted the manuscript; Yu WL helped draft the manuscript; all authors read and approved the final manuscript.
Supported byDoctoral Research Fund Project of the Second Affiliated Hospital of Anhui Medical University, No. 2018BSJJ005; and Clinical Medicine Discipline Construction Project of Anhui Medical University, No. 2021 Lcxk026.
Conflict-of-interest statement: The authors declare that they have no competing interests to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun Sun, MD, Associate Professor, Chief Doctor, Teacher, Department of Critical Care Medicine, The Second Affiliated Hospital, Anhui Medical University, No. 678 Furong Road, Hefei 230601, Anhui Province, China. sunyun15@163.com
Received: January 28, 2021 Peer-review started: January 28, 2021 First decision: February 25, 2021 Revised: March 18, 2021 Accepted: July 5, 2021 Article in press: July 5, 2021 Published online: August 26, 2021
Abstract
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2, poses a significant threat to public health worldwide, and diabetes is considered a risk factor for the rapid progression and poor prognosis of COVID-19. Limited immune function is a clinical feature of COVID-19 patients, and diabetes patients have defects in innate and adaptive immune functions, which may be an important reason for the rapid progression and poor prognosis of COVID-19 in patients with diabetes. We review the possible multiple effects of immune impairment in diabetic patients on the immune responses to COVID-19 to provide guidance for the diagnosis and treatment of diabetic patients with COVID-19.
Core Tip: Diabetes is an important predictor of coronavirus disease 2019 (COVID-19) morbidity and mortality. The immune response impairment presented by diabetes mellitus (DM) may be among the underlying mechanisms of the association between diabetes and COVID-19. DM patients with uncontrolled hyperglycemia are more prone to develop severe COVID-19 due to T cell dysfunction. Therefore, DM is often associated with impaired innate and adaptive immune function, thus greatly increasing the risk of severe acute respiratory syndrome coronavirus 2 infection in DM patients.
