Guo YC, Yao LY, Tian ZS, Shi B, Liu Y, Wang YY. Malignant solitary fibrous tumor of the greater omentum: A case report and review of literature. World J Clin Cases 2021; 9(2): 445-456 [PMID: 33521114 DOI: 10.12998/wjcc.v9.i2.445]
Corresponding Author of This Article
Yuan-Yi Wang, MD, PhD, Associate Professor, Department of Spine Surgery, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. wangyuanyi@jlu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yu-Chen Guo, Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Li-Yu Yao, Department of Pediatric Surgery, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Zhi-Sen Tian, Department of Spine Surgery, China-Japan Union Hospital of Jilin University, Changchun 130021, Jilin Province, China
Bing Shi, Department of Gastroenterology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Ying Liu, Yuan-Yi Wang, Department of Spine Surgery, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Guo YC and Yao LY performed the surgery; Tian ZS validated the figures; Shi B examined and photographed the pathological findings; Liu Y conducted the follow-up; Wang YY conceptualized and organized the study, reviewed the literature and drafted the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yuan-Yi Wang, MD, PhD, Associate Professor, Department of Spine Surgery, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. wangyuanyi@jlu.edu.cn
Received: August 23, 2020 Peer-review started: August 23, 2020 First decision: October 18, 2020 Revised: October 28, 2020 Accepted: November 13, 2020 Article in press: November 13, 2020 Published online: January 16, 2021 Processing time: 138 Days and 5.4 Hours
Abstract
BACKGROUND
Malignant solitary fibrous tumors (SFTs) account for 15%-20% of all SFTs, and malignant SFTs arising from the greater omentum are extremely rare. Most malignant SFTs of the greater omentum are diagnosed via pathological examinations after surgery. In this study, we report a case of malignant omental SFT and review the published literature on this rare malignancy.
CASE SUMMARY
A 64-year-old female presented with an abdominal mass, and underwent exploratory surgery, during which a huge tumor originating from the greater omentum and intraperitoneal implants were identified and resected. The results of the pathological examination, immunohistochemistry staining, and gene sequencing led to the diagnosis of malignant SFT of the greater omentum. The patient died one and a half years later due to tumor recurrence and metastasis.
CONCLUSION
This is the first report of the application of gene sequencing in the diagnosis of malignant SFTs of the greater omentum.
Core Tip: In this study, we present the rare case of a huge malignant solitary fibrous tumor (SFT) of the greater omentum. At presentation, the patient complained of an abdominal mass. After routine imaging examination, she underwent an exploratory laparotomy with a suspected diagnosis of gastrointestinal stromal tumor. Post-operative histological examination and gene sequencing indicated a malignant SFT of the greater omentum. We reviewed and discussed the pre-operative diagnosis, surgical options, and post-operative treatment of reported cases of malignant SFTs of the greater omentum. We suggest the application of gene sequencing in the diagnosis of malignant SFTs.
