Published online Jan 16, 2021. doi: 10.12998/wjcc.v9.i2.445
Peer-review started: August 23, 2020
First decision: October 18, 2020
Revised: October 28, 2020
Accepted: November 13, 2020
Article in press: November 13, 2020
Published online: January 16, 2021
Malignant solitary fibrous tumors (SFTs) account for 15%-20% of all SFTs, and malignant SFTs arising from the greater omentum are extremely rare. Most malignant SFTs of the greater omentum are diagnosed via pathological examinations after surgery. In this study, we report a case of malignant omental SFT and review the published literature on this rare malignancy.
A 64-year-old female presented with an abdominal mass, and underwent exploratory surgery, during which a huge tumor originating from the greater omentum and intraperitoneal implants were identified and resected. The results of the pathological examination, immunohistochemistry staining, and gene sequencing led to the diagnosis of malignant SFT of the greater omentum. The patient died one and a half years later due to tumor recurrence and metastasis.
This is the first report of the application of gene sequencing in the diagnosis of malignant SFTs of the greater omentum.
Core Tip: In this study, we present the rare case of a huge malignant solitary fibrous tumor (SFT) of the greater omentum. At presentation, the patient complained of an abdominal mass. After routine imaging examination, she underwent an exploratory laparotomy with a suspected diagnosis of gastrointestinal stromal tumor. Post-operative histological examination and gene sequencing indicated a malignant SFT of the greater omentum. We reviewed and discussed the pre-operative diagnosis, surgical options, and post-operative treatment of reported cases of malignant SFTs of the greater omentum. We suggest the application of gene sequencing in the diagnosis of malignant SFTs.