Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 26, 2021; 9(15): 3675-3679
Published online May 26, 2021. doi: 10.12998/wjcc.v9.i15.3675
Infiltrating ductal breast carcinoma with monoclonal gammopathy of undetermined significance: A case report
Yi Ma, Sen Cui, Yu-Juan Yin
Yi Ma, Sen Cui, Yu-Juan Yin, Department of Hematology, Qinghai University Affiliated Hospital, Xining 810000, Qinghai Province, China
Author contributions: Ma Y researched the literature and drafted the manuscript; Cui S reviewed the literature and edited the manuscript; Yin YJ edited the paper and suggested clinical information.
Supported by The Second Batch of Qinghai Province “Thousand talents Plan for High-end Innovative Talents,” No. [2017] 5.
Informed consent statement: Informed statement consent was obtained in a routine manner.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Juan Yin, MD, Chief Doctor, Department of Hematology, Qinghai University Affiliated Hospital, No. 29 Shengli Road, Chengxi District, Xining 810000, Qinghai Province, China. 442844625@qq.com
Received: November 30, 2020
Peer-review started: November 30, 2020
First decision: February 28, 2021
Revised: March 3, 2021
Accepted: March 23, 2021
Article in press: March 23, 2021
Published online: May 26, 2021
Processing time: 162 Days and 0.3 Hours
Abstract
BACKGROUND

Infiltrating ductal breast carcinoma with monoclonal gammopathy of undetermined significance (MGUS) is rare and easily misdiagnosed. Most patients are first diagnosed with MGUS. We report a rare case of MGUS secondary to infiltrating ductal breast carcinoma. We also review the literature to analyze the clinical characteristics and diagnostic methods.

CASE SUMMARY

A 51-year-old woman underwent modified radical mastectomy for infiltrating ductal carcinoma of the right breast and was then treated with radiation and chemotherapy. A decreased platelet count was found on routine blood examination, and MGUS was subsequently diagnosed. This is the first report of the occurrence of MGUS after breast cancer surgery.

CONCLUSION

Vigilance is required to distinguish this rare comorbidity from breast plasmacytoma.

Keywords: Infiltrating ductal breast carcinoma; Monoclonal gammopathy of undetermined significance; Breast plasmacytoma; Plasmacytoma; Case report

Core Tip: With age, the risk of monoclonal gammopathy of undetermined significance increases, ranging from 2% to 3% over the age of 50 and approximately 5% over the age of 70. In addition, obesity increases the risk relatively. The cause is unclear. Genetic factors, environmental factors, radiation and chemicals (such as pesticides, herbicides) may have a certain impact on the occurrence of this disease. The risk of infection is higher than normal, the risk of osteoporosis and fractures is increased, and the risk of thrombosis is increased. Tumors with monoclonal gammopathy of undetermined significance should be given more attention.