Fu BB, Zhao JN, Wu SD, Fan Y. Cholesterol gallstones: Focusing on the role of interstitial Cajal-like cells. World J Clin Cases 2021; 9(15): 3498-3505 [PMID: 34046450 DOI: 10.12998/wjcc.v9.i15.3498]
Corresponding Author of This Article
Ying Fan, MD, PhD, Professor, Department of General Surgery, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. coolingpine78@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. May 26, 2021; 9(15): 3498-3505 Published online May 26, 2021. doi: 10.12998/wjcc.v9.i15.3498
Cholesterol gallstones: Focusing on the role of interstitial Cajal-like cells
Bei-Bei Fu, Jian-Nan Zhao, Shuo-Dong Wu, Ying Fan
Bei-Bei Fu, Department of Health Management, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Jian-Nan Zhao, Shuo-Dong Wu, Ying Fan, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Fu BB, Zhao JN, Wu SD, and Fan Y contributed to the collection of the literature, critically revised the manuscript for important intellectual content, and granted final approval of the version to be published.
Supported byNational Natural Science Foundation of China, No. 81000183; and Natural Science Foundation of Liaoning Province, No. 20180550125.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying Fan, MD, PhD, Professor, Department of General Surgery, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. coolingpine78@163.com
Received: October 16, 2020 Peer-review started: October 16, 2020 First decision: December 28, 2020 Revised: January 8, 2021 Accepted: March 17, 2021 Article in press: March 17, 2021 Published online: May 26, 2021
Abstract
Cholesterol gallstone (CG) is a common, frequent biliary system disease in China, with a complex and multifactorial etiology. Declined gallbladder motility reportedly contributes to CG pathogenesis. Furthermore, interstitial Cajal-like cells (ICLCs) are reportedly present in human and guinea pig gallbladder tissue. ICLCs potentially contribute to the regulation of gallbladder motility, and aberrant conditions involving the loss of ICLCs and/or a reduction in its pacing potential and reactivity to cholecystokinin may promote CG pathogenesis. This review discusses the association between ICLCs and CG pathogenesis and provides a basis for further studies on the functions of ICLCs and the etiologies of CG.
Core Tip: Interstitial Cajal-like cells (ICLCs) in the gallbladder have been reported to play an important role in the regulation of gallbladder motility. Loss and/or dysfunction of ICLCs may contribute to motion abnormality of the gallbladder and promote cholesterol gallstone (CG) formation. However, the underlying mechanism is still unclear. This mini-review highlights recent findings on the association between gallbladder ICLCs and CG formation.
