Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 6, 2021; 9(10): 2228-2237
Published online Apr 6, 2021. doi: 10.12998/wjcc.v9.i10.2228
Distribution and drug resistance of pathogens in burn patients in China from 2006 to 2019
Hui Chen, Lin Yang, Lin Cheng, Xiao-Hua Hu, Yu-Ming Shen
Hui Chen, Lin Cheng, Xiao-Hua Hu, Yu-Ming Shen, Department of Burns and Plastic Surgery, Beijing Jishuitan Hospital, Beijing 100035, China
Lin Yang, Department of Healthcare Associated Infection Control, Beijing Jishuitan Hospital, Beijing 100035, China
Author contributions: Chen H, Yang L and Hu XH designed the research study; Chen H, Yang L and Cheng L performed the research; Yang L analyzed the data; Chen H wrote the manuscript; All authors have read and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Beijing Jishuitan Hospital Institutional Review Board.
Informed consent statement: Patients were not required to provide informed consent to the study because the analysis used anonymous data that were obtained after each patient agreed to treatment by signing a written consent form.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Ming Shen, MD, Chief Doctor, Professor, Department of Burns and Plastic Surgery, Beijing Jishuitan Hospital, No. 31 Xinjiekoudong Street, Xicheng District, Beijing 100035, China. shenyumingjst@126.com
Received: January 12, 2021
Peer-review started: January 12, 2021
First decision: January 24, 2021
Revised: January 31, 2021
Accepted: February 24, 2021
Article in press: February 24, 2021
Published online: April 6, 2021
Processing time: 77 Days and 6.5 Hours
Abstract
BACKGROUND

In this study, recent trends in the distribution and drug resistance of pathogenic bacteria isolated from patients treated at a burn ward between 2006 and 2019 were investigated.

AIM

To develop more effective clinical strategies and techniques for the prevention and treatment of bacterial infections in burn patients.

METHODS

Clinical samples with positive bacteria were collected from patients at the burn ward in Beijing Jishuitan Hospital in China between January 2006 and December 2019. The samples were retrospectively analyzed, the distribution of pathogenic bacteria was determined, and the trends and changes in bacterial drug resistance during different period were assessed. Drug resistance in several main pathogenic bacteria from 2006 to 2011 and from 2012 to 2019 was comparatively summarized and analyzed.

RESULTS

Samples from 17119 patients were collected and analyzed from 2006 to 2019. Surprisingly, a total of 7960 strains of different pathogenic bacteria were isolated at this hospital. Among these bacteria, 87.98% (7003/7960) of the strains were isolated from burn wounds, and only 1.34% (107/7960) were isolated from the blood of patients. In addition, 49.70% (3956/7960) were identified as Gram-positive bacteria, 48.13% (3831/7960) were Gram-negative bacteria, and the remaining 2.17% (173/7960) were classified as fungi or other pathogens. Importantly, Staphylococcus aureus (21.68%), Pseudomonas aeruginosa (14.23%), and Staphylococcus epidermidis (9.61%) were the top three pathogens most frequently isolated from patients.

CONCLUSION

In patients treated at the burn ward in this hospital from 2006 to 2019, Staphylococcus aureus and Pseudomonas aeruginosa were the predominant clinical pathogens responsible for bacterial infections. The circumstantial detection and detailed monitoring of the intensity and growth of different pathogenic bacteria in clinical patients as well as tests of drug sensitivity during burn recovery are particularly important to provide guidelines for the application of antibiotics and other related drugs. Careful collection and correct, standard culture of bacterial specimens are also crucial to improve the efficiency of bacterial infection detection. Effective monitoring and timely clinical treatment in patients may help reduce the possibility and rate of infection as well as alleviate the effects of drug resistance among patients in burn centers.

Keywords: Drug resistance; Pathogen distribution; Burn; Bacterial species; Infection

Core Tip: This retrospective study analyzed the pathogenic bacteria isolated from clinical samples from patients on burn wards at our hospital between 2006 and 2019 to determine the distribution of different bacterial species and the long-term trends in bacterial drug resistance. Our findings may direct effective strategies, based on scientific evidence, for the prevention, control, and treatment of infections in burn patients.