Yang L, Liang H, Liu L, Guo L, Ying JM, Shi SS, Hu XS. CD56+ lymphoepithelioma-like carcinoma of the lung: A case report and literature review. World J Clin Cases 2020; 8(7): 1257-1264 [PMID: 32337200 DOI: 10.12998/wjcc.v8.i7.1257]
Corresponding Author of This Article
Xing-Sheng Hu, MD, Doctor, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuannanli, Chaoyang District, Beijing 100021, China. huxingsheng66@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Apr 6, 2020; 8(7): 1257-1264 Published online Apr 6, 2020. doi: 10.12998/wjcc.v8.i7.1257
CD56+ lymphoepithelioma-like carcinoma of the lung: A case report and literature review
Lin Yang, Hua Liang, Li Liu, Lei Guo, Jian-Ming Ying, Su-Sheng Shi, Xing-Sheng Hu
Lin Yang, Li Liu, Lei Guo, Jian-Ming Ying, Su-Sheng Shi, Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Hua Liang, Department of Medical Oncology, Qingdao Central Hospital, Qingdao 266042, Shandong Province, China
Xing-Sheng Hu, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Yang L and Liang H contributed equally to this research. Hu X and Shi S contributed to the conception of the study; Yang L and Liang H collected the clinical data; Liu L and Guo L reviewed the literature; Yang L, Liang H, Liu L, and Ying JM participated in the preparation of the manuscript; Hu XS and Shi SS contributed to the revision of the manuscript; all authors approved the version to be submitted.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xing-Sheng Hu, MD, Doctor, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuannanli, Chaoyang District, Beijing 100021, China. huxingsheng66@163.com
Received: December 25, 2019 Peer-review started: December 25, 2019 First decision: February 20, 2020 Revised: February 24, 2020 Accepted: March 22, 2020 Article in press: March 22, 2020 Published online: April 6, 2020 Processing time: 103 Days and 1.1 Hours
Abstract
BACKGROUND
Lymphoepithelioma-like carcinoma (LELC) is a non-keratinizing carcinoma with rich lymphocytic infiltration, which primarily originates from the nasopharynx. Primary lung LELC is a type of lung cancer with a relatively low incidence. Herein, we report a rare case of lung LELC with expression of CD56. We also performed a literature review to summarize the epidemiological, clinical, and prognostic features of this disease.
CASE SUMMARY
A 51-year-old man was admitted to Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College due to cough and chest pain lasting > 2 mo and 1 wk, respectively. Positron emission tomography-computed tomography and magnetic resonance imaging examinations revealed the presence of a mass in the right upper lobe with enlargement of lymph nodes and multiple bone metastases. According to the results of bronchoscopy and cervical lymph node biopsy, a diagnosis of lung LELC with CD56-positive staining (CD56+ lung LELC) was made. In the literature, 458 cases of lung LELC have been reported. However, only one other case of CD56+ lung LELC has been reported thus far.
CONCLUSION
The mechanism and potential role of CD56 expression in CD56+ lung LELC require further investigation.
Core tip: Primary lung lymphoepithelioma-like carcinoma (LELC) is a rare type of lung carcinoma without established international diagnostic criteria. For this reason, misdiagnosis may occasionally occur and differential diagnosis with other lung primary carcinomas is required. Herein, we report a 51-year old man with CD56-positive lung LELC, which should be differentiated from large cell neuroendocrine carcinoma. A total of 458 cases of lung LELC have been reported in the literature. This case is the second documented case of CD56-positive lung LELC. The mechanism and potential role of CD56 expression in lung LELC require further investigation.
