Published online May 26, 2020. doi: 10.12998/wjcc.v8.i10.1950
Peer-review started: March 5, 2020
First decision: April 1, 2020
Revised: April 1, 2020
Accepted: April 28, 2020
Article in press: April 28, 2020
Published online: May 26, 2020
Processing time: 81 Days and 3.3 Hours
T4 esophageal cancer portends a poor prognosis, particularly when it is complicated by a tracheoesophageal fistula (TEF) either resulting from disease or occurring as a complication of treatment. Patients with TEF that occurs during treatment are commonly treated with palliative intent because fistula-associated treatment complications such as aspiration pneumonia and mediastinitis are associated with high morbidity and mortality. To date, there is no clear evidence on the optimal treatment of T4 esophageal cancer, particularly when a TEF formation occurs.
A 67-year-old gentleman who presented with dysphagia and weight loss. Endoscopy and imaging revealed a T4N1M0 cervical esophageal squamous cell carcinoma. He received image-guided intensity-modulated radiation therapy, with concurrent weekly carboplatin (area under curve 2 mg/mL per minute) and paclitaxel (50 mg/m2 of body surface area). One week after treatment initiation (16.2 Gy thus far), he developed cough on swallowing. A TEF was detected on image-guided radiation therapy using cone-beam computed tomography during the treatment course, for which a tracheal stent was inserted. After discussing the risks and morbidity of continuing treatment, he resumed chemoradiotherapy with an additional radiation dose of 45 Gy in 25 fractions. Three months after completion of chemoradiotherapy, he developed an esophageal stricture that required esophageal stenting and dilatation. The patient remains cancer-free at two year on follow-up. Complete response of esophageal cancer was evident on post-treatment endoscopy and computed tomography imaging, with successful closure of TEF.
This case highlights that successful curative treatment for esophageal cancer complicated by a TEF is possible using novel chemotherapeutic regimens and modern radiation technologies.
Core tip: A trachea-esophageal fistula (TEF) may occur as a complication of treatment for definitive chemoradiotherapy for T4 esophageal cancer, particularly when treating with effective novel agents such as carboplatin-paclitaxel which may induce excellent tumor shrinkage. Because of the high morbidity and mortality associated with TEF, treatment intent is commonly switched from curative to palliative. The successful treatment in this case suggests that patients who develop TEF during treatment should carry on completing the planned treatment after discussion of potential benefits and risks. Excellent treatment responses may be obtained and the TEF may resolve completely.