Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 6, 2020; 8(1): 194-199
Published online Jan 6, 2020. doi: 10.12998/wjcc.v8.i1.194
Unusual presentation of bladder neuroblastoma in a child: A case report
Jia-Bin Cai, Jin-Hu Wang, Min He, Fa-Liang Wang, Jie-Ni Xiong, Jun-Qing Mao, Min-Ju Li, Kun Zhu, Jia-Wei Liang
Jia-Bin Cai, Jin-Hu Wang, Min He, Fa-Liang Wang, Jie-Ni Xiong, Jun-Qing Mao, Min-Ju Li, Division of Surgical Oncology, Department of Pediatric Surgery, Children’s Hospital, Zhejiang University School of Medicine; National Clinical Research Center for Child Health, Hangzhou 310053, Zhejiang Province, China
Kun Zhu, Department of Pathology, Children’s Hospital, Zhejiang University School of Medicine; National Clinical Research Center for Child Health, Hangzhou 310053, Zhejiang Province, China
Jia-Wei Liang, Department of Radiology, Children’s Hospital, Zhejiang University School of Medicine, ; National Clinical Research Center for Child Health, Hangzhou 310053, Zhejiang Province, China
Author contributions: All authors contributed equally to this work; Liang JW collected the image data; Cai JB contributed to manuscript drafting and reviewed the literature; Zhu K performed the pathological interpretation; Mao JQ and Li MJ were the oncologists who treated the patient; Xiong JN collected and the patient’s information in detail; Wang JH, Cai JB, He M, Wang FL were the surgeons who treated the patient; Wang JH was the supervisor who monitored treatment of the patient; all authors issued final approval for the version to submitted.
Supported by Science Technology Research Program of Zhejiang Province, No. 2017C33047; Scientific research project of Zhejiang education department, No. N20140124); Medical Health Science and Technology Project of Zhejiang Provincial Health Commission, No. 2019KY093.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jin-Hu Wang, MD, Associate Professor, Surgical Oncologist, Division of Surgical Oncology, Department of Pediatric Surgery, Children’s Hospital, Zhejiang University School of Medicine;National Clinical Research Center for Child Health, No. 3333 Binsheng Road, Binjiang Distrcict, Hangzhou 310053, Zhejiang Province, China. wjh@zju.edu.cn
Received: October 26, 2019
Peer-review started: October 26, 2019
First decision: November 21, 2018
Revised: November 30, 2019
Accepted: December 13, 2019
Article in press: December 13, 2019
Published online: January 6, 2020
Abstract
BACKGROUND

Neuroblastoma is an extracranial malignant tumor in children that is most often located in the adrenal gland and sympathetic ganglion. Here, we present a rare case of neuroblastoma originating from the urinary bladder.

CASE SUMMARY

A 3-year-old girl presented with lower abdominal pain with micturition. Ultrasound revealed a lower abdominal mass. Abdominal computed tomography scan displayed a solitary mass at the top of the urinary bladder. Blood levels of neuron-specific enolase and lactate dehydrogenase were elevated. We treated the child with partial cystectomy and six courses of chemotherapy, and the outcome at 4-year follow-up was unremarkable.

CONCLUSION

Neuroblastoma should be considered when tumors are located in the urinary bladder, especially in the dome; although this presentation is rare, the prognosis is very good.

Keywords: Neuroblastoma, Urinary bladder, Pelvic neoplasms, Prognosis, Child, Case report

Core tip: Rhabdomyosarcoma is a common bladder malignancy in children. We here report a rare case of bladder neuroblastoma in a child. The patient was treated with a standard strategy and had a good outcome. Our findings suggest that children with neuroblastoma have good prognosis.