Donohue-Cornejo A, Paes de Almeida O, Sánchez-Romero C, Espinosa-Cristóbal LF, Reyes-López SY, Cuevas-González JC. Hyalinizing clear cell carcinoma-a rare entity in the oral cavity: A case report. World J Clin Cases 2020; 8(1): 133-139 [PMID: 31970179 DOI: 10.12998/wjcc.v8.i1.133]
Corresponding Author of This Article
Juan Carlos Cuevas González, PhD, Academic Research, Research Professor, Stomatology Department, Biomedical Sciences Institute, Autonomous University of Ciudad Juárez, Anillo Envolvente del Pronaf s/n, Zona Pronaf Núm. 32315, Cd. Juárez, Chihuahua 32310, México. juan.cuevas@uacj.mx
Research Domain of This Article
Pathology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jan 6, 2020; 8(1): 133-139 Published online Jan 6, 2020. doi: 10.12998/wjcc.v8.i1.133
Hyalinizing clear cell carcinoma-a rare entity in the oral cavity: A case report
Alejandro Donohue-Cornejo, Oslei Paes de Almeida, Celeste Sánchez-Romero, León Francisco Espinosa-Cristóbal, Simón Yobanny Reyes-López, Juan Carlos Cuevas-González
Alejandro Donohue-Cornejo, León Francisco Espinosa-Cristóbal, Simón Yobanny Reyes-López, Juan Carlos Cuevas-González, Stomatology Department, Biomedical Sciences Institute, Autonomous University of Ciudad Juárez, Chihuahua 32310, México
Oslei Paes de Almeida, Celeste Sánchez-Romero, Diagnosis Department, Oral Pathology Section, Dentistry Faculty of Piracicaba, State University of Campinas, São Paulo 13414-903, Brazil
Author contributions: Espinosa-Cristobal LF and Cuevas-González JC treated the patient; Donohue-Cornejo A and Reyes-López SY reviewed the literature and contributed to manuscript drafting; Paes de Almeida O and Sanchez-Romero C performed the histopathological analyses.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Juan Carlos Cuevas González, PhD, Academic Research, Research Professor, Stomatology Department, Biomedical Sciences Institute, Autonomous University of Ciudad Juárez, Anillo Envolvente del Pronaf s/n, Zona Pronaf Núm. 32315, Cd. Juárez, Chihuahua 32310, México. juan.cuevas@uacj.mx
Received: October 15, 2019 Peer-review started: October 15, 2019 First decision: November 13, 2019 Revised: November 18, 2019 Accepted: November 30, 2019 Article in press: November 30, 2019 Published online: January 6, 2020 Processing time: 83 Days and 6.1 Hours
Abstract
BACKGROUND
Hyalinizing clear cell carcinoma (HCCC) is an uncommon tumor that originates in the salivary glands. This neoplasia constitutes less than 1% of minor salivary gland tumors.
CASE SUMMARY
A 67-year-old female visited the maxillofacial surgery department owing to a smooth, slightly yellowish protruding mass on the left side of the floor of the mouth, at the level of the molars; the tumor mass had a soft consistency on palpation and did not adhere to deep planes. The microscopical analysis of the excisional biopsy showed that the lesion was composed of sheets and cords of clear cells separated by thick eosinophilic bands of hyaline collagen. Normal glandular tissue was absent, periodic acid-Schiff with and without diastase stains, and immunohistochemical reactions were performed to confirm the diagnosis. This is the second case reported in the literature of HCCC arising in the floor of the mouth.
CONCLUSION
HCCC is a rare salivary gland tumor that has not been studied extensively. Its diagnosis is usually challenging, because clinically, it can be confused with a benign neoplasm.
Core tip: Hyalinizing clear cell carcinoma is a rare tumor that originates in the salivary glands. This neoplasia constitutes less than 1% of minor salivary gland tumors, the lesion is composed for clear cells that formed compact groups and cords that were separated by thick eosinophilic bands of collagen, with the appearance of hyaline. This carcinoma is a rare salivary gland tumor that has not been studied extensively. Its diagnosis is usually challenging, because clinically, it can be confused with a benign neoplasm.
