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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Primary maxillary chondrosarcoma: A case report
Juan Carlos Cuevas-González, Jesús Oscar Reyes-Escalera, José Luis González, Celeste Sánchez-Romero, León Francisco Espinosa-Cristóbal, Simón Yobanny Reyes-López, Karla Lizette Tovar Carrillo, Alejandro Donohue Cornejo
Juan Carlos Cuevas-González, León Francisco Espinosa-Cristóbal, Simón Yobanny Reyes-López, Karla Lizette Tovar Carrillo, Alejandro Donohue Cornejo, Stomatology Department, Biomedical Sciences Institute, Autonomous University of Ciudad Juárez, Ciudad Juárez 32310, Mexico
Jesús Oscar Reyes-Escalera, Maxillofacial Surgery Department, Faculty of Dentistry, Juarez University of the State of Durango, Durango 34000, Mexico
José Luis González, Madero Pathology Laboratory, Durango 34000, Mexico
Celeste Sánchez-Romero, Molecular Pathology Area, Faculty of Dentistry, University of the Republic, Montevideo 10000, Uruguay
Author contributions: Espinosa-Cristobal LF, Gonzalez JL and Reyes-Escalera JO treated the patient. Tovar Carrillo KL and Reyes-López SY reviewed the literature and contributed to drafting the manuscript. Cuevas González JC, Donohue Cornejo A, and Sanchez-Romero C performed the histopathological and immunohistochemical analyses.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Alejandro Donohue Cornejo, PhD, Academic Research, Research professor, Stomatology Department, Biomedical Sciences Institute, Autonomous University of Ciudad Juárez, Anillo Envolvente del Pronaf S/N, Ciudad Juárez 32310, Mexico. adonohue@uacj.mx
Received: October 26, 2019
Peer-review started: October 26, 2019
First decision: November 21, 2019
Revised: November 22, 2019
Accepted: November 30, 2019
Article in press: November 30, 2019
Published online: January 6, 2020
BACKGROUND
Sarcomas of the head and neck region are rare tumors, constituting less than 1% of malignant neoplasms in this area, of which few cases (20%) originate from bone or cartilage. Chondrosarcoma is a malignant neoplasm that develops in bone, with a predilection for the pelvis, chest wall, and scapula, and is uncommon in the maxilla and jaw. Although this type of lesion has locally aggressive behavior, destroying the affected bone, it can metastasize when it is not diagnosed early and compromise the patient's life.
CASE SUMMARY
On intraoral examination of a 32-year-old female with a tumor in the middle third of the face, a well-defined rise in volume of approximately 3 cm in diameter was observed. Computed tomography with 3-dimensional reconstruction was performed, and we observed that the osteolytic lesion affected the vestibular cortex as the palatal bone. Hematoxylin and eosin staining revealed an appearance that was similar to mature hyaline cartilage, hypercellularity, nuclear and cellular pleomorphism, and multinucleated cells, with significant vacuolization.
CONCLUSION
Determination of the clinical and histopathological characteristics of rare neoplasms in the maxillofacial region, such as chondrosarcomas, allows the pathologist and surgeon to make the appropriate therapeutic decisions, optimizing the patient’s prognosis.
Core tip: Sarcomas of the head and neck region are rare tumors, constituting less than 1% of malignant neoplasms in this area. Although this type of lesion has locally aggressive behavior, destroying the affected bone, it can metastasize when it is not diagnosed early and compromise the patient’s life. Our clinical case is consistent with the age at which chondrosarcoma usually occurs, but this diagnosis was not considered, due its apparently indolent and asymptomatic evolution and lack of pathological changes in the lining mucosa.
