Published online Feb 6, 2019. doi: 10.12998/wjcc.v7.i3.382
Peer-review started: September 23, 2018
First decision: November 14, 2018
Revised: December 4, 2018
Accepted: December 21, 2018
Article in press: December 21, 2018
Published online: February 6, 2019
Processing time: 125 Days and 12.7 Hours
Rivaroxaban is a non-vitamin K antagonist oral anticoagulant that does not require coagulation monitoring based on current recommendations. Our goal is to explore whether routine coagulation monitoring should not be required for all patients receiving oral rivaroxaban, what relationship between routine coagulation abnormalities and bleeding, and how to deal with the above clinical situations through our case and review of the literature.
We report a 67-year-old woman with a history of atrial fibrillation who presented to the hospital with worsening dyspnea and cough. Based on electrocardiogram, venous compression ultrasonography, and computed tomography pulmonary angiography, the diagnosis of atrial fibrillation, deep venous thrombosis, and acute pulmonary embolism was confirmed. Her coagulation assays and renal function were normal on admission; she was not underweight, did not have a history of hemorrhagic disease, and her CHA2DS2-VAS, HAS-BLED, and simplified Pulmonary Embolism Severity Index scores were 3, 0, and 0, respectively. Oral rivaroxaban (15 mg twice daily) was administered. The following day, she presented gastrointestinal and gum bleeding, combined with coagulation abnormalities. Following cessation of rivaroxaban, her bleeding stopped and tests improved over the next 2 d. Rivaroxaban was begun again 3 d after recovery. However, she again presented with gastrointestinal and gum bleeding and the abnormal tests, and the therapy was discontinued. At 30-d follow-up after discharge, she presented normal coagulation tests without bleeding.
Although current guidelines recommend that using non-vitamin K antagonist oral anticoagulants including rivaroxaban do not require coagulation monitoring, a small number of patients may develop routine coagulation test changes and bleeding during rivaroxaban therapy, especially in the elderly. Clinicians should pay attention to these patients and further obtain evidence in practice.
Core tip: Guidelines recommend that patients treated with non-vitamin K antagonist oral anticoagulants do not require coagulation monitoring and show that routine coagulation tests generally do not provide an accurate assessment of effects and bleeding for rivaroxaban. However, our case indicates that in real-world situations, a small number of patients may develop changes in prothrombin time, international normalized ratio, and activated partial thromboplastin time with bleeding during rivaroxaban therapy. The results of literature review suggest that routine coagulation assays may be required in special populations including elderly patients, particularly low-weight females or those with renal insufficiency during oral rivaroxaban.